Results 251 to 260 of about 99,561 (320)

Toll‐like receptor 4 deficiency ameliorates experimental ileitis and enteric neuropathy: Involvement of nitrergic and 5‐hydroxytryptaminergic neurotransmission

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 8, Page 1803-1822, April 2025.
Abstract Background and Purpose Inflammatory bowel disease (IBD) patients display genetic polymorphisms in toll‐like receptor 4 (TLR4) genes, contributing to dysregulate enteric nervous system (ENS) circuits with increased levels of 5‐HT and alteration of the neuroimmune crosstalk.
Sofia Faggin   +12 more
wiley   +1 more source

Epidemiological trends of mechanically ventilated acute respiratory distress syndrome in the twenty-first century: a nationwide, population-based retrospective study. [PDF]

open access: yesJ Intensive Care
Bardají-Carrillo M   +7 more
europepmc   +1 more source

Ruxolitinib for Emergency Treatment of COVID‐19–Associated Cytokine Storm: Findings From an Expanded Access Study

open access: yesThe Clinical Respiratory Journal, Volume 19, Issue 4, April 2025.
In this expanded access program providing ruxolitinib for the emergency treatment of COVID‐19–associated cytokine storm in patients eligible for hospitalization, ruxolitinib 5 mg twice daily (preferred regimen when tolerated) improved clinical status by ≥ 1 point in nearly half of the patients.
Jeffrey Weinstein   +4 more
wiley   +1 more source

Implication of Admission Eosinophil Count and Prognosis of Coronavirus Disease 2019 (COVID‐19) in Elderly Patients With COPD: A Territory‐Wide Cohort Study

open access: yesThe Clinical Respiratory Journal, Volume 19, Issue 4, April 2025.
ABSTRACT Objectives This study aims to investigate the association between elderly patients with COPD with different blood eosinophil on admission and those without COPD and the prognosis of COVID‐19. Method A territory‐wide retrospective study was conducted to investigate the association between elderly COPD patients with different blood eosinophil on
Wang Chun Kwok   +7 more
wiley   +1 more source

Clinical efficacy of invimestrocel for acute respiratory distress syndrome caused by pneumonia: Comparison with historical data using propensity score analysis. [PDF]

open access: yesRegen Ther
Ichikado K   +13 more
europepmc   +1 more source

Real‐world evidence on the utilization, clinical and comparative effectiveness, and adverse effects of newer GLP‐1RA‐based weight‐loss therapies

open access: yesDiabetes, Obesity and Metabolism, Volume 27, Issue S2, Page 66-88, April 2025.
Abstract Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) have emerged as key agents for weight management, based on their marked efficacy as observed in randomized controlled trials. While still limited, real‐world studies on GLP‐1RA use in populations with obesity are increasingly available. This narrative review discusses contemporary real‐world
Reimar W. Thomsen   +3 more
wiley   +1 more source

Immune dysregulation in COVID-19 induced ARDS in kidney transplant recipients revealed by single-cell RNA sequencing. [PDF]

open access: yesSci Rep
Pang J   +12 more
europepmc   +1 more source

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