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Evaluation of the clinical efficiency of COVID drug treatment of clinical-paraclinical parameters in a critical case of COVID-19 with severe pulmonary dysfunction after cesarean section [PDF]

Romanian Journal of Pharmaceutical Practice, 2021
On 11 March 2020 World Health Organization declared the Coronavirus disease 2019 (COVID-19) caused by a novel coronavirus (SARS–CoV–2, 2019 – nCoV) a global pandemic. After a year, there are still many unknowns about peripartum women suffering from COVID
Bianca Laura Sugac +9 more
doaj +1 more source

Efficacy and safety of early prone positioning combined with HFNC or NIV in moderate to severe ARDS: a multi-center prospective cohort study

Critical Care, 2020
Background Previous studies suggest that prone positioning (PP) can increase PaO 2 /FiO 2 and reduce mortality in moderate to severe acute respiratory distress syndrome (ARDS).
L. Ding, Li Wang, Wanhong Ma, Hangyong He +3 more
semanticscholar +1 more source

New potential for an old kid on the block: Impact of premorbid metformin use on lactate kinetics, kidney injury and mortality in sepsis and septic shock, an observational study

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Metformin’s pleomorphic effects may be beneficial in sepsis and septic shock, but its impact remains controversial. Our study is the first to show a significant association between metformin and lactate kinetics in sepsis or septic shock, with a larger decrease in lactate after admission.
Nina Van Moorter +4 more
wiley +1 more source

Clinical features, ventilatory management, and outcome of ARDS caused by COVID-19 are similar to other causes of ARDS

Intensive Care Medicine, 2020
The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known.
C. Ferrando +442 more
semanticscholar +1 more source

Advances in the use of exosomes for the treatment of ALI/ARDS

Frontiers in Immunology, 2022
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical clinical syndrome with high morbidity and mortality. Currently, the primary treatment for ALI/ARDS is mainly symptomatic therapy such as mechanical ventilation and fluid ...
Chang Liu, K. Xiao, L. Xie
semanticscholar +1 more source

Neutrophil activation and neutrophil extracellular traps (NETs) in COVID‐19 ARDS and immunothrombosis

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
Neutrophils play a role in the immunopathology SARS‐CoV‐2 infection by triggering the formation of NETs, producing cytokines including interleukin‐8 (CXCL8), and mediating the recruitment of other immune cells to regulate inflammation, which can lead to ARDS.
Maria Candida Cesta +8 more
wiley +1 more source

Defining phenotypes and treatment effect heterogeneity to inform acute respiratory distress syndrome and sepsis trials: secondary analyses of three RCTs

Efficacy and Mechanism Evaluation, 2021
Background: Sepsis and acute respiratory distress syndrome are two heterogeneous acute illnesses with high risk of death and for which there are many ‘statistically negative’ randomised controlled trials.
Manu Shankar-Hari +15 more
doaj +1 more source

Prone position in ARDS patients: why, when, how and for whom

Intensive Care Medicine, 2020
In ARDS patients, the change from supine to prone position generates a more even distribution of the gas–tissue ratios along the dependent–nondependent axis and a more homogeneous distribution of lung stress and strain.
C. Guérin +10 more
semanticscholar +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian +3 more
wiley +1 more source

Host–Viral Interactions Revealed among Shared Transcriptomics Signatures of ARDS and Thrombosis: A Clue into COVID-19 Pathogenesis

TH Open, 2020
Severe novel corona virus disease 2019 (COVID-19) infection is associated with a considerable activation of coagulation pathways, endothelial damage, and subsequent thrombotic microvascular injuries.
Aastha Mishra, Shankar Chanchal, Mohammad Z. Ashraf +2 more
doaj +1 more source

lung
internal medicine
respiratory distress syndrome

humans
intensive care medicine
covid-19

anesthesia
3. good health
respiration, artificial