Results 91 to 100 of about 11,092,458 (299)

Introducing TAXI: a Transportable Array for eXtremely large area Instrumentation studies

, 2014
A common challenge in many experiments in high-energy astroparticle physics is the need for sparse instrumentation in areas of 100 km2 and above, often in remote and harsh environments.
Haungs, A., Karg, T., Kleifges, M., Nahnhauer, R., Sulanke, K. -H.   +4 more
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Democratic Impact of ICT in Africa Informations- und Kommunikationstechnologien, politische Handlungsfähigkeit und demokratisches Regieren in Afrika

Africa Spectrum, 2012
This paper takes a critical look at the view that the Internet can serve as a laboratory of political experimentation for reconfiguring the repertories of political actions.
Alexandra Dobra
doaj  

Studies of the Newbury mining area [PDF]

, 1956
Thesis. (B.S.) Massachusetts Institute of Technology. Dept. of Geology and Geophysics, 1956.MIT copy bound with: A nuclear free precession magnetometer for prospecting / Alexander Richard Aitken.
Clark, Robert Bucknam, Engels, Peter David   +1 more
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Access to Resources and Predictability in Armed Rebellion: The FAPC’s Short-lived “Monaco” in Eastern Congo Zugang zu Ressourcen und Berechenbarkeit von bewaffneten Rebellionen: Das kurzlebige “Monaco” der FAPC im östlichen Kongo

Africa Spectrum, 2011
This article discusses the impact of economic resources on the behaviour of an armed group. The availability of resources, and the presence of “lootable” resources in particular, is presumed to have a negative impact on the way an armed group behaves ...
Kristof Titeca
doaj  

Investigation of the Relationship of Earthquakes and Underground Waste Disposal in The El Dorado Area, Arkansas [PDF]

, 1991
From December, 1983 to September, 1989 twelve small earthquakes were recorded for the El Dorado, Arkansas area. Magnitudes of these earthquakes were well below damaging levels.
Cox, Randel, VanArsdale, Roy B.
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Concurrent atmospheric heatwaves intensify marine heatwaves through air-sea heat flux change in the Mediterranean Sea

Communications Earth & Environment
Atmospheric and marine heatwaves are intensifying under climate change, increasingly co-occurring with significant impacts on ecosystems and society. Despite their significance, the effects of their concurrence remain poorly understood, particularly the ...
Laura Paredes-Fortuny, Francisco Pastor, Samira Khodayar   +2 more
doaj   +1 more source