Results 91 to 100 of about 22,464,620 (250)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Laporan Maret 2019 Perpustakaan Universitas Medan Area
, 2019 73 HalamanPuji syukur kepada Allah SWT, karena atas Karunia dan Rahmat-Nya laporan bulanan Perpustakaan Universitas Medan Area Bulan Maret 2019 dapat tersusun dengan baik.
Perpustakaan, Universitas Medan Area
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Laporan Juli 2018 Perpustakaan Universitas Medan Area
, 2018 44 HalamanPuji syukur kepada Allah SWT, karena atas Karunia dan Rahmat-Nya laporan bulanan Perpustakaan Universitas Medan Area Bulan Juli 2018 dapat tersusun dengan baik.
Perpustakaan, Universitas Medan Area
core +1 more source
Laporan April 2019 Perpustakaan Universitas Medan Area
, 2019 51 HalamanPuji syukur kepada Allah SWT, karena atas Karunia dan Rahmat-Nya laporan bulanan Perpustakaan Universitas Medan Area Bulan April 2019 dapat tersusun dengan baik.
Perpustakaan, Universitas Medan Area
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Interdyscyplinarność a zagrożenia strukturalne dla socjologii krytycznej. Artykuł dyskusyjny
Przeglad Socjologii JakosciowejW artykule przedstawiono pogląd na temat zagrożeń wynikających dla socjologii, w szczególności socjologii krytycznej, ze strukturalnych przemian w naukach społecznych, których legitymizacją jest coraz większe znacznie interdyscyplinarności. Jak wskazano,
Tomasz Zarycki
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Culture e Studi del Sociale, 2019 The present article investigates the new developments and challenges of social sciences and humanities in the era of globalization and underlines the importance of social sciences` intersection with interdisciplinary and transregional collaborative ...
Filomena Riccardi
doaj
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source