Results 91 to 100 of about 478,663 (300)

1391. Vancomycin Area Under the Curve (AUC) to Predict Nephrotoxicity: A Systematic Review and Meta-Analysis of Observational Studies [PDF]

Open Forum Infectious Diseases, 2018
Abstract Background Recent studies have proposed monitoring vancomycin area under the curve (AUC) as a more precise method of attaining goal exposures compared with trough monitoring. Different dosing methods and different exposure-toxicity thresholds have been proposed. Therefore, we aimed to analyze
Aljefri, Doaa, Avedissian, Sean, Rhodes, Nathaniel J, Postelnick, Michael, Scheetz, Marc H   +4 more
openaire   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Comparison of diagnostic reliability based on the area under the curve (AUC). [PDF]

, 2018
Comparison of diagnostic reliability based on the area under the curve (AUC).
Byungho Oh (3129564), Kee-Yang Chung (3129555), Sejung Yang (793510), Chanki Yu (4919437), Sang Wook Lee (433729), Wonoh Kim (4919434), Jinwoong Jung (4919431)   +6 more
core   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Evaluation of Performance of the Truncated Area Under Curve (AUC) as a Primary Pharmacokinetic Parameter in Bioequivalence Studies

Journal of Bioequivalence & Bioavailability, 2010
Background and Objective: Prolonged pharmacokinetic sampling is a challenge for successful conduction of the bioequivalence studies for drugs having long elimination half-lives. The regulatory authorities have recommended an alternative to consider the partial AUC (AUC0-72) for studying bioequivalence.
Suhas Sahebrao Khandave, Shahoo Vasant Onkar, Satish Vitthal Sawant   +2 more
openaire   +1 more source

Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li, Guilin Meng, Zijie Wang, Xiao Hu, Jing Cheng, Chu Chen, Tiannan Yang, Jiaxin Luo, Zizhen Meng, Xueyun Liu, Qi Li   +10 more
wiley   +1 more source

Clinical Validation of Plasma p‐217tau in Neurological Diseases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐217tau is a minimally invasive but specific biomarker for diagnosing Alzheimer's disease (AD). However, its disease specificity remains to be clinically evaluated. We validated the reliability of the p‐217tau biomarker in 12 other neurological diseases.
Takeshi Kawarabayashi, Takumi Nakamura, Ryoma Takahashi, Tetsuya Ueda, Seiji Kinoshita, Chikage Uchida, Takashi Sugawara, Kentaro Hashimoto, Kunihiko Ishizawa, Masakuni Amari, Hiroo Kasahara, Yoshio Ikeda, Masamitsu Takatama, Mikio Shoji   +13 more
wiley   +1 more source

The area under the curve (AUC) of SROC (summary receiver operating characteristic) curves. [PDF]

, 2016
The area under the curve (AUC) of SROC (summary receiver operating characteristic) curves.
Jing Xu (1234089), Ke Deng (278265), Hongyuan Jia (3146985), Xuelei Ma (147562), Chenjing Zhu (3146982), Zhigong Wei (3146988), Yue Xiao (830802)   +6 more
core   +1 more source

Area under the curve (AUC) of the K-MBI cutoff scores corresponding to mRS grades. [PDF]

, 2020
Area under the curve (AUC) of the K-MBI cutoff scores corresponding to mRS grades.
Min Cheol Joo (8309712), Jongmin Lee (568159), Seung Yeol Lee (8374719), Won Hyuk Chang (8309727), Gyung-Jae Oh (822845), Yang-Soo Lee (7109867), Min Kyun Sohn (8309715), Ji Yoo Choi (8309730), Yun-Hee Kim (113108), So Young Lee (259302), Il Yoel Kim (8374722), Young Hoon Lee (1431625), Jeonghoon Ahn (3109791), Junhee Han (8309724), Yong-Il Shin (3279387), Deog Young Kim (6194549), Soo-Yeon Kim (3932393), Sam-Gyu Lee (8309718), Sung Hyun Kang (8309733)   +18 more
core   +1 more source

The categorisation of the Short Warwick Edinburgh Mental Wellbeing Scale scores: an exploration from an epidemiological perspective

Frontiers in Psychiatry
BackgroundThere has been a notable increase in the utilisation of SWEMWBS as a measure of mental well-being globally. To enhance its interpretability for both healthcare professionals and laypeople, categorising SWEMWBS scores is considered beneficial ...
Lawrence T. Lam, Lawrence T. Lam, Lawrence T. Lam, Mary K. Lam   +3 more
doaj   +1 more source