Results 171 to 180 of about 3,042,026 (332)

Does calculation method matter for targeting vancomycin area under the curve? [PDF]

J Antimicrob Chemother, 2022
Chang J, Patel D, Vega A, Claeys KC, Heil EL, Scheetz MH.   +5 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A pilot study evaluating mid-point vancomycin concentrations to estimate pharmacokinetics and area under the curve: a prospective study. [PDF]

BMC Infect Dis
AbuSara A, Abdelrahman D, Awad W, Le J, Shapiro S, Nazer L.   +5 more
europepmc   +1 more source

Area under the curve: Comparing the value of factor VIII replacement therapies in haemophilia A. [PDF]

Haemophilia, 2023
Persson S, Berndt C, Engstrand S, Trinczek A, Carlsson KS, Berntorp E.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Effect of introducing a pharmacist-led support system on the administration rate of vancomycin loading dose and the 0–24-hour area under the concentration–time curve [PDF]

Tatsuya Tai, Takahiro Motoki, Masahiro Watanabe, Naohiro Kurokawa, Sayaka Yamashita, Kazunori Yamaguchi, Hiroaki Tanaka, Yuichi Muraki, Shinji Kosaka   +8 more
openalex   +1 more source

Comparable area under the curve for three risk scores to detect interstitial lung disease in patients with rheumatoid arthritis: an external validation. [PDF]

Rheumatol Int
Blomberg E, Wahlin B, Södergren A.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A mixed effects model for analyzing area under the curve of longitudinally measured biomarkers with missing data

, 2021
Luoxi Shi, Dorothy K. Hatsukami, Joseph S. Koopmeiners, Chap T. Le, Neal L. Benowitz, Eric C. Donny, Xianghua Luo   +6 more
openalex   +2 more sources

Estimating area under the curve from graph-derived summary data: a systematic comparison of standard and Monte Carlo approaches. [PDF]

BMC Med Res Methodol
Titensor S, Ebbert J, Corte KD, Corte DD.   +3 more
europepmc   +1 more source