Results 211 to 220 of about 127,696,973 (248)

An evaluation of numerical integration algorithms for the estimation of the area under the curve (AUC) in pharmacokinetic studies

Biopharmaceutics and Drug Disposition, 1995
AbstractSix numerical integration algorithms based on linear and log trapezoidal methods as well as four cubic‐spline methods were proposed for estimation of area under the curve (AUC). These six different algorithms were implemented using IMSL/IDLTM command language and evaluated using data simulated under five different dosing conditions and two ...
F L Tse
exaly   +3 more sources

Evaluating Performance of Software Defect Prediction Models Using Area Under Precision-Recall Curve (AUC-PR)

2019 2nd International Conference on Advancements in Computational Sciences (ICACS), 2019
Software defect prediction (SDP) models are used to improve effort and testing estimate of software by identifying defective modules beforehand. Precision, recall/true positive rate and false positive rate have been used to evaluate the performance of models.
Zeeshan Rana
exaly   +3 more sources

Application of Hill's equation for estimating area under the concentration-time curve (AUC) and use of time to AUC 90% for expressing kinetics of drug disposition

Journal of Pharmacological and Toxicological Methods, 2009
Half life and its derived pharmacokinetic parameters are calculated on an assumption that the terminal phase of drug disposition follows a constant rate of disposition. In reality, this assumption may not necessarily be the case. A new method is needed for analyzing PK parameters if the disposition does not follow a first order PK kinetic.Cumulative ...
exaly   +3 more sources

Area Under the Curve (AUC)

2020
exaly   +2 more sources

Doing More With Less: Pragmatic Implementation of Vancomycin Area-Under-the-Curve (AUC) Monitoring

Journal of Pharmacy Practice, 2021
Universal area-under-the-curve (AUC) guided vancomycin therapeutic drug monitoring (TDM) is resource-intensive, cost-prohibitive, and presents a paradigm shift that leaves institutions with the quandary of defining the preferred and most practical method for TDM.
Joanne Huang, Jeannie D. Chan, Thu Nguyen, Rupali Jain, Zahra Kassamali Escobar   +4 more
openaire   +2 more sources

CYCLOSPORIN A (CyA) MONITOrING BY CALCULATION OF AREA UNDER THE CURVE (AUC)

Nephrology, 2000
Background The introduction of CyA resulted in a significant prolongation in renal transplant survival but was complicated by the difficulty in distinguishing between transplant rejection and drug toxicity. More recently the conversion of stable transplant recipients to the microemulsion form of CyA resulted in significant nephrotoxicity at trough ...
Goodman D, DeCaneva R Power D, Murphy B, Agar J   +3 more
openaire   +1 more source

Bias and variance of extrapolated tails for area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC)

Journal of Pharmacokinetics and Biopharmaceutics, 1992
The usual formulas for the extrapolated values of AUC and AUMC from tn to infinity produce estimates that are biased. An empirical correction factor is shown to reduce both bias and variance of estimates. The fitted value Cz at the last time-point tn should normally be used in the formulas, rather than the measured concentration Cn.
openaire   +2 more sources

Optimum numerical integration methods for estimation of area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC)

Journal of Pharmacokinetics and Biopharmaceutics, 1992
Eleven numerical methods for estimation of AUC (including 4 new methods) and 22 methods for AUMC (including 8 new methods) were tested on large simulated noisy datasets representing bolus, oral and infusion concentration-time profiles. Some methods were unacceptable because their mean error was large; these included a commonly recommended form of the ...
openaire   +2 more sources

Evaluating the Safety of Trough Versus Area Under the Curve (AUC)-Based Dosing Method of Vancomycin With Concomitant Piperacillin-Tazobactam

Journal of Pharmacy Technology, 2022
Background: Vancomycin and piperacillin-tazobactam (VPT) is a common antibiotic combination used in hospitals, and there has been increasing data indicating that the combination is associated with increased rates of acute kidney injury (AKI). It is unclear if the dosing method of vancomycin would mitigate the risk of AKI seen with VPT.
Cassandra Karas, Kyle Manning, Darrell T. Childress, Elizabeth W. Covington, Melanie M. Manis   +4 more
openaire   +2 more sources

area under the curve (AUC)

2009
Area under the concentration/time curve of a substance in pharmacokinetic investigations; describes the extent of the bioavailability of a drug.
openaire   +1 more source