Results 41 to 50 of about 109,317 (301)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ProtASR2

, 2019
ProtASR is an evolutionary framework to reconstruct ancestral protein sequences accounting for structural constraints. It is known that protein evolution is influenced by the protein structure.
Arenas, Miguel (8174454), Bastolla, Ugo (8174457), Arenas, Miguel, Bastolla, Ugo   +3 more
core   +1 more source

Mutation in a SARS-CoV-2 Haplotype from Sub-Antarctic Chile Reveals New Insights into the Spike’s Dynamics

Viruses, 2021
The emergence of SARS-CoV-2 variants, as observed with the D614G spike protein mutant and, more recently, with B.1.1.7 (501Y.V1), B.1.351 (501Y.V2) and B.1.1.28.1 (P.1) lineages, represent a continuous threat and might lead to strains of higher ...
Jorge González-Puelma, Jacqueline Aldridge, Marco Montes de Oca, Mónica Pinto, Roberto Uribe-Paredes, José Fernández-Goycoolea, Diego Alvarez-Saravia, Hermy Álvarez, Gonzalo Encina, Thomas Weitzel, Rodrigo Muñoz, Álvaro Olivera-Nappa, Sergio Pantano, Marcelo A. Navarrete   +13 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Assessment of the prospects of the neocomian sediments for the presence of hydrocarbon fluid through geochemical core studies

Известия высших учебных заведений: Нефть и газ
This paper presents the results of geochemical studies on core samples from Neocomian sediments located in the northern part of Western Siberia.In traditional geological exploration of deep-submerged facilities with complex geological structures ...
D. A. Kobylinskiy, E. Yu. Neelova, M. D. Zavatskiy   +2 more
doaj   +1 more source

Snow Cover Change as a Climate Indicator in Brunswick Peninsula, Patagonia

Frontiers in Earth Science, 2018
Snow cover changes are assessed for the Brunswick Peninsula in southern Patagonia (52.9°S to 53.5°S), located on the transition between the wet Pacific Ocean area and the drier leeward side of the Andes. We use the Normalized Difference Snow Index (NDSI)
Francisco Aguirre, Francisco Aguirre, Jorge Carrasco, Tobias Sauter, Christoph Schneider, Katherine Gaete, Katherine Gaete, Enrique Garín, Rodrigo Adaros, Nicolas Butorovic, Ricardo Jaña, Gino Casassa, Gino Casassa   +12 more
doaj   +1 more source

Trophic Niche Dynamics and Diet Partitioning of King Crab Lithodes santolla in Chile’s Sub-Antarctic Water

Diversity, 2022
The southern king crab Lithodes santolla is one of the most economically important fishery species in the southern waters of the Atlantic and Pacific Oceans.
Claudia Andrade, Cristóbal Rivera, Erik Daza, Eduardo Almonacid, Fernanda Ovando, Flavia Morello, Luis Miguel Pardo   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Los mercados como campos y arenas. Hacia una etnoeconomía de los procesos mercantiles

Alteridades, 2014
La tesis central del artículo señala que no existe un solo tipo de mercados sino que hay una variedad elevada de éstos, se pretende demostrar además, que el fenómeno mercantil no se agota en la oferta o la demanda ni es un fenómeno meramente económico ...
Juan Castaingts Teillery
doaj