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ARF6, a component of intercellular bridges, is essential for spermatogenesis in mice
Developmental Biology, 2023Male germ cells are connected by intercellular bridges (ICBs) in a syncytium due to incomplete cytokinesis. Syncytium is thought to be important for synchronized germ cell development by interchange of cytoplasmic factors via ICBs. Mammalian ADP-ribosylation factor 6 (ARF6) is a small GTPase that is involved in many cellular mechanisms including but ...
Hetty N. Wong +3 more
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Getting invasive with GEP100 and Arf6
Nature Cell Biology, 2008When cancers spread, they detach from their neighbouring cells and invade the surrounding tissues to reach blood or lymphatic vessels. EGF receptors induce cancer invasion by directly activating GEP100, one of several potential activators of the GTP-binding protein Arf6.
Valderrama, F, Ridley, A J
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1995
Abstract A chicken-processed pseudogene, termed CPS1 (accession number P26990; Alsip and Konkel 1986), was originally cloned by serendipity and thought to be a novel Ras protein, as no other small GTP-binding proteins were known at that time. With the cloning of a human homologue (accession number P26438; Tsuchiya, etal.
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Abstract A chicken-processed pseudogene, termed CPS1 (accession number P26990; Alsip and Konkel 1986), was originally cloned by serendipity and thought to be a novel Ras protein, as no other small GTP-binding proteins were known at that time. With the cloning of a human homologue (accession number P26438; Tsuchiya, etal.
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Arf6 mediates Schwann cell differentiation and myelination
Biochemical and Biophysical Research Communications, 2015During development of the peripheral nervous system (PNS), Schwann cells wrap neuronal axons, becoming the myelin sheaths that help axonal functions. While the intercellular signals controlling the myelination process between Schwann cells and peripheral neurons are well studied, the transduction of these signals in Schwann cells still remains elusive.
Tomohiro, Torii +8 more
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A Regulatory Role for ARF6 in Receptor-Mediated Endocytosis
Science, 1995Adenosine diphosphate-ribosylation factor 6 (ARF6), ARF6 mutants, and ARF1 were transiently expressed in Chinese hamster ovary cells, and the effects on receptor-mediated endocytosis were assessed. Overexpressed ARF6 localized to the cell periphery and led to a redistribution of transferrin receptors to the cell surface and a decrease in the rate of ...
C, D'Souza-Schorey +3 more
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Assays and Properties of the ArfGAPs, AMAP1 and AMAP2, in Arf6 Function
2005The GTPase-activating protein (GAP) domain for Arfs primarily consists of a zinc-finger structure, which is not present in known GAPs for the other Ras-superfamily GTPases. More than 20 genes have been found to encode proteins bearing the ArfGAP domain in the human genome: a number that is much larger than that of the Arf isoforms. Several Arf isoforms,
Shigeru, Hashimoto +4 more
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Preparation of Myristoylated Arf1 and Arf6 Proteins
2003Paul A, Randazzo, Henry M, Fales
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