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Two-Photon, Ratiometric, Quantitative Fluorescent Probe Reveals Fluctuation of Peroxynitrite Regulated by Arginase 1.

Analytical Chemistry, 2021
Peroxynitrite, a transient reactive oxygen species (ROS), is believed to play a deleterious role in physiological processes. Herein, we report a two-photon ratiometric fluorescent probe that selectively reacts with peroxynitrite yielding a >200-fold ...
Shiyu Chen   +6 more
semanticscholar   +1 more source

The human arginases and arginase deficiency

Journal of Inherited Metabolic Disease, 1998
AbstractArginase is the final enzyme in the urea cycle. Its deficiency is the least frequently described disorder of this cycle. It results primarily in elevated blood arginine, and less frequently in either persistent or acute elevations in blood ammonia.
R, Iyer   +5 more
openaire   +2 more sources

Arginase deficiency

The Indian Journal of Pediatrics, 1997
Hyperargininemia due to arginase deficiency is a rare, inherited, urea cycle disorder. We report a case of arginase deficiency in a 5-year old boy presenting with mild hyperammonemia, hyperargininemia, and dibasic aminoaciduria.
R, Christopher   +2 more
openaire   +2 more sources

Review of arginase as a promising biocatalyst: characteristics, preparation, applications and future challenges

Critical Reviews in Biotechnology, 2021
As a committed step in the urea cycle, arginase cleaves l-arginine to form l-ornithine and urea. l-Ornithine is essential to: cell proliferation, collagen formation and other physiological functions, while the urea cycle itself converts highly toxic ...
Mengli Li   +4 more
semanticscholar   +1 more source

A phase I/II study of safety and efficacy of the arginase inhibitor INCB001158 plus chemotherapy in patients (Pts) with advanced biliary tract cancers.

, 2021
311Background: Arginase, secreted in the tumor microenvironment by myeloid suppressor cells, is a major regulator of arginine-mediated immune response.
M. Javle   +11 more
semanticscholar   +1 more source

Arginase-1 deficiency

Journal of Molecular Medicine, 2015
Arginase-1 (ARG1) deficiency is a rare autosomal recessive disorder that affects the liver-based urea cycle, leading to impaired ureagenesis. This genetic disorder is caused by 40+ mutations found fairly uniformly spread throughout the ARG1 gene, resulting in partial or complete loss of enzyme function, which catalyzes the hydrolysis of arginine to ...
Yuan Yan, Sin   +3 more
openaire   +2 more sources

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