Results 271 to 280 of about 843,121 (388)

De Novo Design of Specific Heterotrimeric Collagen‐Like Peptides via Genetic Algorithm

Advanced Science, EarlyView.
GRACE is a computational algorithm producing peptide sequences that will reliably fold into composition and registration‐controlled collagen‐like triple helices with user‐specified thermal stability. Additionally, GRACE allows users to specify the inclusion of biologically relevant (or other) sequences to automatically create tailored triple helices ...
Thi H. Bui, Oluwakamisi Adetunji, Carson C. Cole, Le Tracy Yu, Caroline M. Peterson, Jeffrey D. Hartgerink   +5 more
wiley   +1 more source

Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma. [PDF]

J Exp Clin Cancer Res
Hanssen KM, Murray J, Pandher R, Alfred S, Gamble LD, Brand J, Mosmann E, Kusuma FK, Mak C, Kearns A, Kamili A, Atkinson C, Minchaca AZ, Bertoldo J, Ziegler DS, Mussai F, Cheng PNM, Norris MD, Fletcher JI, Haber M.   +19 more
europepmc   +1 more source

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

Advanced Science, EarlyView.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin, Zhiyang Li, Xiaotong Zhu, Wanbing Zhou, Xiansheng Lu, Jiali Zheng, Jie Lin   +6 more
wiley   +1 more source

Gastric Bypass Associated Hyperammonemia (GaBHA): A Case Study, Scoping Review of the Literature, and Proposed New Pathophysiologic Mechanism. [PDF]

Metabolites
Fenves AZ, Hatipoglu D, Robinson JC, Rothkopf MM.   +3 more
europepmc   +1 more source

Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting

Advanced Science, EarlyView.
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang, Rongmao Qiu, Yongjie Huang, Yinghua Liu, Kui Huang, Suwen Zhao, Yang Li   +6 more
wiley   +1 more source

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.

ACS Chemical Biology, 2016
M. Eram, Yudao Shen, Magdalena M. Szewczyk, Hong Wu, G. Senisterra, Fengling Li, Kyle V. Butler, H. U. Kaniskan, B. A. Speed, C. D. Seña, A. Dong, H. Zeng, M. Schapira, M. Schapira, P. Brown, C. Arrowsmith, C. Arrowsmith, D. Barsyte-Lovejoy, Jing Liu, M. Vedadi, M. Vedadi, Jian Jin   +21 more
semanticscholar   +1 more source

Citrulline Supplementation Improves Microvascular Function and Muscle Strength in Middle-Aged and Older Adults with Type 2 Diabetes. [PDF]

Nutrients
Figueroa A, Dillon KN, Levitt DE, Kang Y.   +3 more
europepmc   +1 more source

ARGININE FEEDING AND CREATINE-CREATININE EXCRETION IN MAN

, 1929
Elizabeth C. Hyde, William C. Rose
openalex   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Metabolic dysregulation in pulmonary fibrosis: insights into amino acid contributions and therapeutic potential. [PDF]

Cell Death Discov
Zheng H, Zhang L, Wang C, Wang Y, Zeng C.   +4 more
europepmc   +1 more source