Results 301 to 310 of about 805,592 (386)

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Amino acids shape the metabolic and immunologic landscape in the tumor immune microenvironment: from molecular mechanisms to therapeutic strategies. [PDF]

Cancer Biol Med
Lin Z, Chang C, Zhao S, Fang L, Wang P.
europepmc   +1 more source

Arginine metabolism and nutrition in growth, health and disease

Amino Acids, 2009
Guoyao Wu, Guoyao Wu, F. Bazer, T. Davis, S. Kim, Peng Li, J. M. Rhoads, M. Satterfield, Stephen B. Smith, T. Spencer, Yulong Yin   +10 more
semanticscholar   +1 more source

Highly Stretchable, Self‐Healable, and Conductive Gelatin Methacryloyl Hydrogel for Long‐Lasting Wearable Tactile Sensors

Advanced Science, EarlyView.
Gelatin methacryloyl hydrogel, which possesses high stretchability, tensile strength, toughness, and autonomous self‐healing capability at room temperature, is developed through the introduction of interpenetrating networks, hierarchical hydrogen bonds (weak and strong H‐bonds), and borate ester bonds.
Zhikang Li, Bin Wang, Jijian Lu, Yumeng Xue, Jiaxiang Wang, Boqing Jia, Gengyu Han, Yihe Zhao, Muhammad Afzal Khan Qureshi, Lan Yu, Kang Zhao, Min Li, Ping Yang, Dejiang Lu, Libo Zhao   +14 more
wiley   +1 more source

Transport of the uremic toxin symmetric dimethylarginine (SDMA) by renal transport proteins. [PDF]

Amino Acids
Scherpinski LA, Fromm MF, Maas R, König J.   +3 more
europepmc   +1 more source

BInD: Bond and Interaction‐Generating Diffusion Model for Multi‐Objective Structure‐Based Drug Design

Advanced Science, EarlyView.
Can a generative model design molecules that truly understand their targets? BInD, a diffusion‐based framework, co‐generates 3D molecules and their interactions with proteins by learning target‐specific interacting patterns. With knowledge‐based guidance and NCI‐driven optimization, BInD balances affinity, geometry, and drug‐likeness – pushing the ...
Joongwon Lee, Wonho Zhung, Jisu Seo, Woo Youn Kim   +3 more
wiley   +1 more source

Uga3 influences nitrogen metabolism in <i>Saccharomyces cerevisiae</i> by modulating arginine biosynthesis. [PDF]

Microb Cell
Urtasun N, Muñoz SA, Arán M, Bermúdez-Moretti M.   +3 more
europepmc   +1 more source

Protein arginine methylation: a prominent modification and its demethylation

Cellular and Molecular Life Sciences, 2017
Juste Wesche, Sarah Kühn, B. Kessler, M. Salton, Alexander Wolf   +4 more
semanticscholar   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Functional Dynamics of Arginine Mono- and Di-Methylation. [PDF]

Cells
Wang X, Zhu B, Winn R, Lu S, Wang H.
europepmc   +1 more source