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Multi-Faceted Arginine: Mechanism of the Effects of Arginine on Protein
Current Protein & Peptide Science, 2014Arginine is widely used in such applications as protein refolding, solubilization of proteins and small molecules, protein and small molecule formulation, column chromatography and viral inactivation as summarized in this review. What makes arginine effective in these applications is largely based on its ability to suppress protein-protein interactions
Yoshiko Kita, Tsutomu Arakawa
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2013
Recent studies suggest that alterations of the arginine metabolome and a dysregulation of nitric oxide (NO) homeostasis play a role in the pathogenesis of asthma. L-Arginine, a semi-essential amino acid, is a common substrate for both the arginases and NO synthase (NOS) enzyme families.
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Recent studies suggest that alterations of the arginine metabolome and a dysregulation of nitric oxide (NO) homeostasis play a role in the pathogenesis of asthma. L-Arginine, a semi-essential amino acid, is a common substrate for both the arginases and NO synthase (NOS) enzyme families.
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Effect of arginine and canavanine on arginine messenger RNA synthesis
Biochemical and Biophysical Research Communications, 1971Summary The level of messenger RNA for the arg ECBH gene cluster in Escherichia coli was determined by hybridization of 3 H-pulse-labeled RNA with DNA from 80darg. L-Arginine repressed the level of hybridizable message 7 to 24 fold lower than that observed in arginine-deprived cells.
Palmer Rogers +3 more
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Protein arginine methylation: from enigmatic functions to therapeutic targeting
Nature reviews. Drug discovery, 2021Qin Wu +3 more
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Transport of L-Arginine in Arginine-Deprived Endothelial Cells
Biochemical and Biophysical Research Communications, 1995In vascular endothelium, L-arginine (ARG) plays a crucial role as a substrate for various metabolic pathways, one of which is the synthesis of bioregulatory nitric oxide. Transport of ARG across the cell membrane determines intracellular substrate availability.
S. Zink +3 more
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Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate.
Biochemistry, 1988Previous studies have shown that murine macrophages immunostimulated with interferon gamma and Escherichia coli lipopolysaccharide synthesize NO2-, NO3-, and citrulline from L-arginine by oxidation of one of the two chemically equivalent guanido ...
M. Marletta +4 more
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The lung in the balance: arginine, methylated arginines, and nitric oxide
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2007the lung is a major source of nitric oxide (NO), be it from nitric oxide synthase (NOS) III in the endothelium of the vast pulmonary circulation, NOS II in the epithelium of the large surface area of the airways, or NOS I in the nonadrenergic noncholinergic nerves ([6][1]).
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Vascular endothelial cells synthesize nitric oxide from L-arginine
Nature, 1988R. Palmer, D. Ashton, S. Moncada
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The regulation, functions and clinical relevance of arginine methylation
Nature reviews. Molecular cell biology, 2019E. Guccione, S. Richard
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The arginine transfer reaction
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1968Abstract The incorporation of arginine into hot trichloroacetic acid-insoluble material by a 150 000 · g supernatant fraction from sheep thyroid cytoplasm has been studied. 1. 1. Incorporated arginine contains a free α-amino group as judged by the fluorodinitrobenzene reaction.
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