Results 131 to 140 of about 147,103 (258)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Argumentation and problem-solving ability of elementary school students

, 2017
Este trabalho objetivou descrever como estudantes do 8° ano do Ensino Fundamental resolvem problemas, partindo da hipótese inicial que a capacidade argumentativa dos estudantes tem influência sobre a capacidade de resolução de problemas. Para a coleta de dados, utilizou-se um teste da capacidade de resolver problemas e uma entrevista.
Ruppenthal, Raquel, Chitolina Schetinger, Maria Rosa   +1 more
openaire   +1 more source

Improving student confidence to engage in productive discourse on controversial public health topics: an evaluation of course effectiveness. [PDF]

Front Public Health
Zori G, Nyakhar S, Hack G, Pomeranz J, King LM.   +4 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Writing as formation: supervising AI use in early-career medical authorship. [PDF]

Front Artif Intell
Jacinto T.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Peirce's revenge on the Chinese Room. [PDF]

Front Psychol
Loginov EV, Vasilyev VV, Kuznetsov AV, Volkov DB, Besedin AP, Mertsalov AV.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Influences of an Argumentative Discourse Learning Environment on Eighth Graders’ Scientific Argumentation Ability

US-China Education Review B, 2017
null Jeng-Fung Hung, null Men-An Pan, null Kun Lee   +2 more
openaire   +1 more source

Free Riding on the Harm Principle. [PDF]

Public Health Ethics
White L.
europepmc   +1 more source