Results 91 to 100 of about 3,160,332 (330)

Agent Based Models and Complex Individuals: An Epistemological Analysis

Œconomia, 2001
In the relevant literature concerning Agent Based Models (ABMs), there seems to be agreement that they may replace the rational agent model of neoclassical economics.
Solange Regina Marin, Brena Paula M. Fernande, Daniel de S. Vasconcelos   +2 more
doaj  

Statistical mechanics of kinks on a gliding screw dislocation

Physical Review Research, 2020
The ability of a body-centered-cubic metal to deform plastically is limited by the thermally activated glide motion of screw dislocations, which are line defects with a mobility exhibiting complex dependence on temperature, stress, and dislocation ...
Max Boleininger, Martin Gallauer, Sergei L. Dudarev, Thomas D. Swinburne, Daniel R. Mason, Danny Perez   +5 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Mémoire et théorie de l’histoire chez Dilthey [PDF]

Lo Sguardo - Rivista di Filosofia, 2014
In this paper I undertake an interpretation of the concept of memory in the work of Wilhelm Dilthey and of its role in the framework of his theory of history.
Jeffrey Andrew Barash
doaj  

Medición científica entre la intervención y la representación

Valenciana, 2016
Se analiza la propuesta empirista de van Fraassen en torno a la medición científica considerando las objeciones hechas a las teorías representacionalistas de la medición, para argumentar que la medición es un proceso complejo iterativo en el que teoría y
Gilda Macedo Mira Andreu
doaj   +1 more source

Necessary and sufficient factors in employee downsizing? A qualitative comparative analysis of lay-offs in France and the UK, 2008-2013 [PDF]

, 2016
Embedded in the literature on financialization and institutional approaches, this study is an examination of the causal factors of employee downsizing in two institutionally dissimilar settings, France and the UK, using the fuzzy sets variant of ...
Ahmadjian, Ahmadjian, Appelbaum, Appelbaum, Atanassov, Bessler, Braumoeller, Brav, Bronars, Bruslerie, Campbell, Cascio, Clark, Clark, Clark, Dafsaliens, Datta, Davies, Dobbin, Emmenegger, Engelen, Farber, Goergen, Goergen, Gospel, Gourevitch, Goyer, Goyer, Greckhamer, Gumbrell-McCormick, Hall, Hall, Hardie, Howarth, Howell, Jacoby, Kahan, Korczynski, Krippner, Mahoney, Mahoney, Munoz-Bullon, OECD, Ragin, Ragin, Ragin, Roe, Schneider, Thelen, Thelen, Thompson, Whitley, Zwan   +52 more
core   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Primordial RNA Replication and Applications in PCR Technology [PDF]

, 2013
The emergence of self-replication and information transmission in life's origin remains unexplained despite extensive research on the topic. A hypothesis explaining the transition from a simple organic world to a complex RNA world is offered here based ...
Palasek, Stan
core  

Reexamining “Free Energy Rate Density” as a Complexity Metric

Journal of Big History
Cosmic Evolution, by Eric J. Chaisson is arguably one of the original “core” texts of big history. Despite being published over 20 years ago, it is still relevant for its explanation of the cosmological and thermodynamic underpinnings of the evolution of
Ken Solis
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source