Results 271 to 280 of about 1,659,451 (344)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

What is critical metascience and why is it important? [PDF]

Front Psychol
Rubin M.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Child-Directed Speech Facilitates Semantic Role Learning: A Machine Learning Approach. [PDF]

Open Mind (Camb)
Huber E, Bickel B, Stoll S.
europepmc   +1 more source

When nurses are held accountable for AI-driven clinical decisions, they must be engaged early and meaningfully. [PDF]

Health Aff Sch
Reading Turchioe M, Wieben A, Sun C, Baker C, Galatzan BJ.   +4 more
europepmc   +1 more source

How to communicate evidence against catchy erroneous arguments? [PDF]

Eur J Public Health
Magid A, Nitzan D, Marchandise C, Mexia R, Aragon de Leon E, McCallum A.   +5 more
europepmc   +1 more source

'The AVMA must withdraw support for overturning Proposition 12'. [PDF]

Vet Rec
McCulloch S.
europepmc   +1 more source

Moral foundations and attitudes towards supervised consumption services: a regional moderation study. [PDF]

Harm Reduct J
Dryden RP, Pijl EM.
europepmc   +1 more source

Argumentation und Argument

, 1980
openaire   +1 more source