Results 111 to 120 of about 484,117 (322)

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

open access: yesAdvanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu   +14 more
wiley   +1 more source

A CLASS OF ARITHMETICAL FUNCTIONS [PDF]

open access: yesProceedings of the National Academy of Sciences, 1955
openaire   +2 more sources

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

open access: yesAdvanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su   +15 more
wiley   +1 more source

Multicharged Zwitterions form Superior Antifouling Interfaces

open access: yesAdvanced Science, EarlyView.
Bolaamphiphilic multicharged sulfobetaine zwitterion forms self‐assembled monolayer for antifouling applications and vesicular aggregates for drug delivery applications. Abstract The long‐term prevention of unwanted protein and microbial accumulation on surfaces, including medical devices, remains a significant and largely unresolved challenge. Decades
Declan Meehan   +6 more
wiley   +1 more source

Systematic Benchmarking of a Noise‐Tolerant Conductive Hydrogel Electrode for Epidermal Bioelectronics

open access: yesAdvanced Science, EarlyView.
General schematic of the approach. Abstract Conventional Silver/Silver Chloride (Ag/AgCl) electrodes remain the clinical standard for electrophysiological monitoring but are hindered by poor skin conformity, mechanical rigidity, and signal degradation, particularly under motion or sweat.
Nazmi Alsaafeen   +11 more
wiley   +1 more source

From Complex Shaping to Mirror Finish: Additive Manufacturing of Aerospace‐grade Cf/SiC Space Optics

open access: yesAdvanced Science, EarlyView.
An integrated additive manufacturing route combines selective laser sintering, engineered interphases, and optimized silicon infiltration to fabricate complex Cf/SiC composites. The approach enables precise shaping, high mechanical performance, and excellent optical reflectivity, offering a scalable solution for advanced aerospace optics with both ...
Buhao Zhang   +8 more
wiley   +1 more source

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