Results 201 to 210 of about 9,985,560 (316)

Pharmacometric evaluation of pre‐referral rectal artesunate in children with severe malaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Parenteral artesunate is the preferred first‐line treatment for severe malaria. Pre‐referral rectal artesunate suppositories are recommended where parenteral treatment is inaccessible. In this study, we compared dihydroartemisinin exposure and model‐predicted early parasite clearance following rectal artesunate and intravenous artesunate in ...
Ayorinde Adehin, Marie A. Onyamboko, Caterina Fanello, Nicholas J. White, Nicholas P. J. Day, Richard M. Hoglund, Joel Tarning   +6 more
wiley   +1 more source

An arithmetic–geometric mean inequality for singular values and its applications

, 2017
L. Zou
semanticscholar   +1 more source

An inequality for arithmetic and harmonic means

The following result is proved: If \(A_ n\) and \(H_ n\) (resp. \(A_ n'\) and \(H_ n')\) denote the arithmetic and harmonic means of \(x_ 1,\ldots,x_ n\) (resp. \(1-x_ 1,\ldots,1-x_ n)\) with \(x_ i\in(0,1/2]\) \((i=1,\ldots,n)\), then \[ H_ n-H_ n'\leq A_ n-A_ n', \] with equality if and only if \(x_ 1=\cdots=x_ n\).
openaire   +1 more source

Plasma and breast milk pharmacokinetics of suvorexant in healthy lactating women

British Journal of Clinical Pharmacology, EarlyView.
Aim This paper aims to evaluate the plasma and breast milk pharmacokinetics of suvorexant, an orexin receptor antagonist used to treat insomnia at a maximum dose of 20 mg, in healthy lactating women. Methods The paper reports on an open‐label Phase 1 study in 12 healthy lactating women.
Jacqueline McCrea, Andrew Litovsky, Prachi Wickremasingha, Nairita Ghosal, Brad Roadcap, Robert Valesky, Robin Lee, Leea D. Reed, Ming Wang, Wei Fang, Rebecca Wrishko   +10 more
wiley   +1 more source

No developmental fronto-parietal shift in brain activation during mental arithmetic across the lifespan: A registered report. [PDF]

PLoS One
Artemenko C, Avcil M.
europepmc   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Symbolic and non-symbolic geometric abilities across development and in individuals with dyscalculia and dyslexia. [PDF]

iScience
Castaldi E, Anobile G, Marazzi M, Federici S, Angelelli P, Turi M.   +5 more
europepmc   +1 more source

Pharmacokinetic and pharmacodynamic interaction of enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, with glimepiride and metformin in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aims Enavogliflozin, a sodium‐glucose cotransporter 2 inhibitor, is expected to be coadministered with antihyperglycaemic drugs with different mechanisms of action. This study aimed to investigate the pharmacokinetic (PK) and pharmacodynamic (PD) interactions between enavogliflozin, glimepiride and metformin.
Kyungrin Chang, Yoonjin Kim, Daye Jung, Jae Min Cho, Joo‐Youn Cho, SeungHwan Lee   +5 more
wiley   +1 more source

Low Time-Weighted Parathyroid Hormone Is Associated with Malnutrition-Inflammation and Functional Dependence in Maintenance Hemodialysis. [PDF]

Nutrients
Levin Iaina N, Petkutsa A, Habashi N, Gurevich E.   +3 more
europepmc   +1 more source

Single‐subject designs in character education: Methods for rigorous, contextual, and practitioner‐led research

British Educational Research Journal, EarlyView.
Abstract Character education research is often constrained by blunt methodological tools. Surveys capture breadth without depth; case studies offer richness but lack replicability; and randomised controlled trials (RCTs), though indispensable at the policy level, are costly, disruptive and ill‐suited to everyday practice with individual pupils.
Shane McLoughlin
wiley   +1 more source