Results 71 to 80 of about 41,603 (233)

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano, Giulia Apprato, Serena Francisco, Giuseppe Ermondi, Giulia Caron   +4 more
wiley   +1 more source

Linking regional and global functional trait data: insights from mammal communities in a fragmented Atlantic Forest landscape

Oikos, EarlyView.
Accurate functional trait data are essential for understanding ecosystem services and processes in fragmented landscapes. We evaluated whether the global EltonTraits 1.0 database adequately represents the functional structure of mammal communities in forest fragments and restoration sites in a highly fragmented Atlantic Forest landscape.
Maria F. R. Godoi, Fábio Z. Farneda, Alan D. Pereira, Marcos Akira‐ Umeno, Fernanda C. Marques, Marcos Robalinho Lima   +5 more
wiley   +1 more source

Differences in mammal community response to highway construction across different levels of human land use

Wildlife Biology, EarlyView.
Worldwide, transportation agencies have been involved in road mitigation efforts to reduce road mortality and promote connectivity of endangered species. Baseline data on how mammals respond to highway construction, however, are rarely collected in road mitigation and monitoring studies, including in the USA.
Thomas J. Yamashita, Jason V. Lombardi, Zachary M. Wardle, Michael E. Tewes, John H. Young   +4 more
wiley   +1 more source

Wildlife temporal behaviors in response to human activity changes during and following COVID‐19 park closures

Wildlife Biology, EarlyView.
With urbanization reducing the amount of available wildlife habitat, and outdoor recreation increasing the human activity within wildlife habitats, it is important to understand the effects of human activity on animal behavior. This study examined how the reduction in human presence in urban parks in Gainesville, Florida, affected the temporal ...
Maya Fives, Matthew Hallett
wiley   +1 more source

Lures do not increase box‐trapping success of an endangered felid in South Texas

Wildlife Society Bulletin, EarlyView.
We used a randomized design and linear regression to assess whether visual (compact disc [CD] and ribbon), and olfactory (musk and ocelot urine) lures would increase capture success of three mesocarnivores (ocelots [Leopardus pardalis], bobcats [Lynx rufus], and coyotes [Canis latrans]) with box traps baited with a live bird from December 2023 to April
Ashley M. Reeves, Landon R. Schofield, Alynn M. Martin, Aidan B. Branney, Lindsay A. Martinez, Georgia Harris, Meghan Murphy, Jason E. Sawyer   +7 more
wiley   +1 more source

Photometric Depth Super-Resolution

, 2019
This study explores the use of photometric techniques (shape-from-shading and uncalibrated photometric stereo) for upsampling the low-resolution depth map from an RGB-D sensor to the higher resolution of the companion RGB image. A single-shot variational
Cremers, Daniel, Haefner, Bjoern, Peng, Songyou, Quéau, Yvain, Verma, Alok   +4 more
core   +3 more sources

Sensory Biology of the Franciscana (Pontoporia blainvillei, Pontoporiidae, Cetartiodactyla): Ontogenetic Modifications of Vibrissae and Vibrissal Crypts

Integrative Zoology, EarlyView.
The transition of cetaceans from a terrestrial to an aquatic environment involved a crucial sensory adaptation to environments with limited visibility. Vibrissae, important mechanoreceptors, undergo an ontogenetic transformation in odontocetes. This research describes the histomorphology of vibrissae and crypts at different developmental stages ...
Cecilia Mariana Krmpotic, Cleopatra Mara Loza, Alejo Carlos Scarano, Pedro Fernando Andrés‐Laube, Francisco Acuña, Juan Pablo Loureiro, Carolina Natalia Zanuzzi, Nicolás Nahuel Castro, María Teresa Pombo, Lorenzo von Fersen, Claudio Gustavo Barbeito   +10 more
wiley   +1 more source

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

eLife, 2016
A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here, we
Michael Sulak, Lindsey Fong, Katelyn Mika, Sravanthi Chigurupati, Lisa Yon, Nigel P Mongan, Richard D Emes, Vincent J Lynch   +7 more
doaj   +1 more source

Hierarchical Differentiable Fluid Simulation

Computer Graphics Forum, EarlyView.
We introduce a two‐step algorithm that significantly reduces memory usage for solving control problems using differentiable fluid simulation techniques: our method first optimizes for bulk forces at reduced resolution, then refines local details over sub‐domains while maintaining differentiability. In trading runtime for memory, it enables optimization
Xiangyu Kong, Arnaud Schoentgen, Damien Rioux‐Lavoie, Paul G. Kry, Derek Nowrouzezahrai   +4 more
wiley   +1 more source