Results 81 to 90 of about 13,322 (217)
Cell Proliferation, EarlyView.In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu +6 more
wiley +1 more source
Hypercortisolism: Causes, Consequences and Clinical Significance – A Review of Pathophysiology
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Hypercortisolism or Cushing syndrome is a heterogeneous clinical spectrum caused by chronic glucocorticoid excess, ranging from exogenous Cushing syndrome to rare endogenous aetiologies and the increasingly recognised entity of mild autonomous cortisol secretion (MACS). Physiological cortisol production is tightly regulated by the hypothalamic–
Mohamed Eldib +3 more
wiley +1 more source
The FEBS Journal, EarlyView.Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff +2 more
wiley +1 more source
The FEBS Journal, EarlyView.This review summarizes recent structures of the UBR4 complex, a giant E4 ubiquitin ligase which recognizes proteins with pre‐existing ubiquitin modifications and marks them for degradation. The UBR4 complex uses a large arena lined with substrate interaction modules to select features on ubiquitinated substrates, such as the presence of N‐degrons or ...
Daniel B. Grabarczyk, Tim Clausen
wiley +1 more source
β-catenin in Plants and Animals: Common Players but Different Pathways
Frontiers in Plant Science, 2014 Manisha eSharma +2 more
doaj +1 more source
MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions
Immunology, EarlyView.MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula +6 more
wiley +1 more source
Journal of Anatomy, EarlyView.Two‐toed sloths use their thoracic limbs for more frequent and greater suspensory support than three‐toed sloths and have muscle architectural properties consistent with stability of the pectoral girdle, enhanced flexor force/torque applied at the shoulder and elbow joints, and grip on the support as indicated by their myology. Abstract Two‐toed sloths
C. S. Tucker +4 more
wiley +1 more source
Journal of Anatomy, EarlyView.We describe the endocranial anatomy of Metacheiromys marshi. Decrease in olfaction and eye movement control occurred through time in Pholidotamorpha and is likely linked to fossorial adaptations. The development of the orbital gyrus might be related to the evolution of myrmecophagy and the emergence of a protrusile tongue in early Pholidotamorpha ...
Eduard Cabasés Bru +4 more
wiley +1 more source
Extracting vitalities: Cuts in Indigenous women's bodies‐territories (Brazil)
Medical Anthropology Quarterly, EarlyView.Abstract In this article, I explore the connections between the medicalization of childbirth and environmental devastation through Guarani‐Mbyá understandings of life and the living. I argue that the cuts made to Guarani‐Mbyá women's vaginas (episiotomies) in Brazilian hospitals are experienced and situated on the same cosmopolitical level as the cuts ...
Maria Paula Prates
wiley +1 more source