Results 91 to 100 of about 47,033 (312)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Public Goods and Territory [PDF]
The paper will attempt to demostrate the fundamental importance of public goods in the performance of any territory or economy. After discussing the concept and definition of public goods, the most important of them will be reviewed along with their ...
Javier Alfonso-Gil
core
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Saint John’s Red Head Battery: A Forgotten Military Artifact of Confederation [PDF]
, 2012 In the early 1860s, driven by the threat of war with the United States, British army engineers and local contractors built a coast artillery battery on top of the red-coloured bluffs overlooking the eastern approach to Saint John harbour.
Sarty, Roger
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Influence of maneuverability on helicopter combat effectiveness [PDF]
A computational procedure employing a stochastic learning method in conjunction with dynamic simulation of helicopter flight and weapon system operation was used to derive helicopter maneuvering strategies. The derived strategies maximize either survival
Falco, M., Smith, R.
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Progress in aircraft design since 1903 [PDF]
Significant developments in aviation history are documented to show the advancements in aircraft design which have taken place since 1903. Each aircraft is identified according to the manufacturer, powerplant, dimensions, normal weight, and typical ...
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
ACUTE TOXICITY OF A NIGERIAN ARMAMENT FACTORY EFFLUENT ON OREOCHROMIS NILOTICUS (LINNAEUS+)
Academy Journal of Science and Engineering, 2009 Effluents from a Nigerian armament factory were characterized using standard methods. The acute toxicity of this effluent on Oreochromis niloticus was determined in a 96h static bioassay under laboratory conditions, in 3%, 6%, 9%, 12% and 15% effluent ...
G.B ONWUMERE
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