Results 71 to 80 of about 47,033 (312)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The Sites of the Early Nomads on the North-East Periphery of the Sarmatian World
Нижневолжский археологический вестник, 2019 The paper publishes new materials of the early Sarmatian time from the North-East periphery of the Sarmatian World – the Southern forest-steppe and steppe zones of the Trans-Ural region within the bounds of the modern Chelyabinsk region. The territory of
Aleksander D. Tairov
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Våpenkappløpene i Asia- og Stillehavsområdet
Internasjonal Politikk, 2016 Etter flere tiår med rask økonomisk vekst satser en rekke stater i Asia- og Stillehavsområdet på å utvikle sterkere militærmakt. I denne artikkelen hevdes det at det nå foregår flere våpenkappløp i regionen.
Stig Lysklætt +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
'Spectacles within doors': panoramas of London in the 1790s [PDF]
, 2008 Edinburgh University Press allows authors to retain the right to post the definitive version of the contribution, as published by EUP, in the Institutional Repository or in a disciplinary repository one year following publication in print.
Autobiographical Recollections Tom +4 more
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
The Slovenian Lands as the Armed Frontier of the Holy Roman Empire
Fasciculi Archaeologiae Historicae, 2017 In the late Middle Ages, the Slovenian lands formed a major bulwark defending the south-eastern borders of the Holy Roman Empire. Relatively little is known of the military organisation in this strategically significant region due to the absence of ...
Tomaž Lazar
doaj +1 more source