Results 61 to 70 of about 3,606 (267)

The Sites of the Early Nomads on the North-East Periphery of the Sarmatian World

open access: yesНижневолжский археологический вестник, 2019
The paper publishes new materials of the early Sarmatian time from the North-East periphery of the Sarmatian World – the Southern forest-steppe and steppe zones of the Trans-Ural region within the bounds of the modern Chelyabinsk region. The territory of
Aleksander D. Tairov
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Våpenkappløpene i Asia- og Stillehavsområdet

open access: yesInternasjonal Politikk, 2016
Etter flere tiår med rask økonomisk vekst satser en rekke stater i Asia- og Stillehavsområdet på å utvikle sterkere militærmakt. I denne artikkelen hevdes det at det nå foregår flere våpenkappløp i regionen.
Stig Lysklætt   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Sword of the early sarmatian period from the Ik-Zay interfluve

open access: yesПоволжская археология, 2015
A sword discovered in 2001 as a stray find in the area of Chaply village (Aznakayevsky District of the Tatarstan Republic) is analyzed in the article. The sword is kept at Aznakayevsky Local History Museum.
Izmaylov Iskander L
doaj  

Science and Armaments [PDF]

open access: yesNature, 1923
DR. FRENCH'S reply (NATURE, February 10) to my letter in the issue of January 20 does not touch upon the essential idea which I desired to express. I did not raise the question of the dispensability or indispensability of armaments at the present moment: a question on which a great deal might be said, but one which, I think, is somewhat outside the ...
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

The Slovenian Lands as the Armed Frontier of the Holy Roman Empire

open access: yesFasciculi Archaeologiae Historicae, 2017
In the late Middle Ages, the Slovenian lands formed a major bulwark defending the south-eastern borders of the Holy Roman Empire. Relatively little is known of the military organisation in this strategically significant region due to the absence of ...
Tomaž Lazar
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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