Results 41 to 50 of about 24,023 (208)

Self-repairing performance of wear-reduction serpentine-reinforced iron composites based on orthogonal experiments

Materials & Design
Self-repairing materials can effectively heal early-stage micro-damage; however, their performance is strongly governed by thermo-mechanical conditions during friction.
Yanli Yin, Helong Yu, Xiang Xiao, Zhanyong Song, Hongmei Wang, Xinyuan Zhou, Xiaochao Ji   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Study on Thermophysical Properties and Electrical Conductivity Characteristics of Combustion Products from Propellants with Ionization Seeds

Aerospace
Detailed knowledge regarding the thermophysical properties and electrical conductivity of the combustion products derived from solid propellants is essential for the optimized design and operation of solid-fuel rocket engines employing ...
Chunlin Chen, Lei Chang, Baoquan Mao, Qijin Zhao, Renbin Li, Xianghua Bai   +5 more
doaj   +1 more source

Application of aluminium alloys for military purposes

Vojnotehnički Glasnik, 2000
Owing to their strength-to-weight ratio, plasticity, fracture toughness and corrosion resistance, aluminium alloys are widely applied in military industry.
Borivoje V. Veljanovski , Miomir Kalezić , Vencislav Grabulov , Milutin Nikačević   +3 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Novel progress of laser cladding and its applications in material fabrication

Cailiao gongcheng
Laser cladding uses a high-energy laser to rapidly melt cladding materials with the substrate surface， forming a metallurgically bonded coating upon solidification.
DONG Shiyun, SUN Zhe, QIN Lu, YAN Shixing   +3 more
doaj   +1 more source

From Heraldry to Genealogy from Silverware

Genealogy, 2019
A Coat of Arms engraved on a piece of silverware allowed the identification of the parties concerned, and the elucidation of the details of their marriage and ancestries. The Arms themselves have an interesting provenance.
Bruce Durie
doaj   +1 more source