Results 51 to 60 of about 24,023 (208)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

International contexts of war in Ukraine

Vojenské rozhledy, 2015
The article deals with the international context of the latent war in Ukraine. It explains the recent history of the post-Soviet area in the light of Galutng’s theory of positive and negative peace.
Jan Eichler
doaj   +1 more source

Rapid visual detection of FecB gene expression in sheep

Open Life Sciences, 2020
Sheep play an important role in agricultural production and people’s lives, and fecundity is one of the most important economic traits of sheep for sheep breeders.
Liu Li, Hu Ruirui, Li Cunyuan, Li Xiaoyue, Ni Wei, Yao Rui, Zhang Mengdan, Li Huixiang, Xu Yueren, Ullah Yaseen, Hu Shengwei   +10 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Study on the damage prediction model of PTFE/AL projectiles on the basis of regression analysis

AIP Advances
Polytetrafluoroethylene/aluminum (PTFE/AL) projectiles can effectively enhance the damage efficiency of traditional projectiles. Numerical simulation via ANSYS AUTODYN and data analysis via Origin are effective means to help predict the damage efficiency
Huan Tong, Cong Hou, Xiangrong Li, Yongkang Chen, Lei Yang   +4 more
doaj   +1 more source

Spatiotemporal multi-sensor characterization of melt pool dynamics in laser directed energy deposition

Materials & Design
Laser directed energy deposition (L-DED) technology has gained significant attention for its potential in manufacturing complex components. However, its industrial adoption is constrained by process fluctuations that cause variability in quality and ...
Gen Tian, Yang Zhao, Wenyu Wang, Guofeng Han, Zhiqiang Ren, Xiaoming Wang, Lu Lu, Sheng Zhu   +7 more
doaj   +1 more source

On the Symbolism of Rain in A Farewell to Arms

University of Chitral Journal of Linguistics and Literature, 2019
This paper critically analyzes the symbolic use of rain in A Farewell to Arms (1929). The researcher has applied Sapir-Whorf Hypothesis as a research tool for the analysis of the text.
Muhammad Rahman
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

القوْل، المرأة والثورة التحريرية

إنسانيات, 2004
“El gaoul” is a popular kind of poetry It is sung collectively by women in the southern Oran region, on the occasion of religious and familial festivities.
عبد القادر خليفي
doaj   +1 more source