Results 71 to 80 of about 16,682,845 (349)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Behavioral Arms Control and East Asia

Journal for Peace and Nuclear Disarmament
Growing political and military tensions between China and the United States make it necessary to think of novel arms control approaches on nuclear weapons and certain emerging technologies, designed to include China and other actors.
Ulrich Kühn, Heather Williams
doaj   +1 more source

Genetic Modifiers of Parkinson's Disease: A Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the associations of LRRK2 p.G2019S, GBA1 p.N409S, polygenic risk scores (PRS), and APOE E4 on PD penetrance, risk, and symptoms. Methods We conducted a US‐based observational case–control study using data from the 23andMe Inc. and Fox Insight Genetic Substudy (FIGS) databases.
Matthew J. Kmiecik, Michael V. Holmes, Pierre Fontanillas, Giulietta M. Riboldi, Ruth B. Schneider, Jingchunzi Shi, Anna Guan, Susana Tat, Steven Micheletti, Keaton Stagaman, Josh Gottesman, David A. Hinds, Joyce Y. Tung, 23andMe Research Team, Stella Aslibekyan, Lucy Norcliffe‐Kaufmann   +15 more
wiley   +1 more source

Occupational health and safety regulations in China: development process, enforcement challenges, and solutions

Frontiers in Public Health
BackgroundOccupational health is closely related to China’s public health system and the construction of a healthy China. The purpose of this paper is to summarize the current health status of China’s occupational population and the dilemmas faced by ...
Xinyu Xu, Xinyu Xu, Xinyu Xu, Peihua Ren, Peihua Ren, Wenyan Shi, Wenyan Shi, Feidan Deng, Feidan Deng, Qingfeng Wang, Qingfeng Wang, Shaoteng Shi, Shaoteng Shi, Jingchun Shen, Jingchun Shen, Guoqiang Dong, Jing Han, Jing Han, Jing Han, Jing Han   +19 more
doaj   +1 more source

Orphans and Icons: Small Arms Control and Armed Groups in Southeast Asia

, 2008
Over the past decade, the international community has initiated programmes and policies to redress the worldwide availability and circulation of small arms and light weapons.
Koorey, Stephanie Leeanne Kinvig
core   +1 more source

Characteristics of Cerebral Palsy in the Midwestern US

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebral palsy (CP) is the most common lifelong motor disability worldwide. Yet, data is limited on how CP manifests in the US. Our objective was to characterize and determine factors affecting functional outcomes in a large population of young people with CP in the Midwestern US.
Susie Kim, Kelsey Steffen, Lauren Gottschalk‐Henneberry, Jennifer Miros, Amy Robichaux‐Viehoever, Karen Taca, Bhooma R. Aravamuthan   +6 more
wiley   +1 more source

Nerve Excitability in Asymptomatic Carriers and Amyotrophic Lateral Sclerosis Patients With C9orf72

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We investigated the effects of C9orf72 mutation carriership on peripheral nerve excitability in asymptomatic individuals from families with a history of C9orf72 amyotrophic lateral sclerosis (ALS) and patients. Methods We included 47 asymptomatic individuals from families with a history of C9orf72 ALS, of whom 23 were carriers (C9 ...
Diederik J. L. Stikvoort García, H. Stephan Goedee, Leonard H. van den Berg, Boudewijn T. H. M. Sleutjes   +3 more
wiley   +1 more source

Coordination of multiple robot arms [PDF]

Kinematic resolved-rate control from one robot arm is extended to the coordinated control of multiple robot arms in the movement of an object. The structure supports the general movement of one axis system (moving reference frame) with respect to another
Barker, L. K., Soloway, D.
core   +1 more source

Improved electromechanical master-slave manipulator [PDF]

, 1968
Electric master-slave manipulator uses force multiplication and allows the operator to remotely control the slave arm. Both the master and slave arms execute seven distinct motions by a specially designed force-reflecting servo having a one to one ...
Forster, G., Goertz, R., Grimson, J., Mingesz, D., Potts, C.   +4 more
core   +1 more source

Using Electronic Health Records to Derive Control Arms for Early Phase Single‐Arm Lung Cancer Trials: Proof‐of‐Concept in Randomized Controlled Trials

Clinical pharmacology and therapy, 2019
Oncology drug development increasingly relies on single‐arm clinical trials. External controls (ECs) derived from electronic health record (EHR) databases may provide additional context.
G. Carrigan, S. Whipple, W. Capra, Michael D. Taylor, Jeffrey S. Brown, Michael Lu, B. Arnieri, Ryan Copping, K. Rothman   +8 more
semanticscholar   +1 more source