Results 51 to 60 of about 398,162 (307)

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

The role of military assistance in the problem of arms control : the Middle East, Latin America, and Africa [PDF]

open access: yes, 1963
"August 10, 1964.""1398. Rev. 9/15/64."--handwritten on coverIncludes bibliographical references"Prepared under contract with the United States Arms Control and Disarmament Agency."General considerations -- The regional role of military assistance: the ...
Kelleher, Catherine McArdle
core  

NATO's Role in Nuclear Non-Proliferation and Arms Control: A (Critical) History

open access: yes, 2021
This paper looks at the interaction between the Atlantic Alliance and the main arms-control negotiations of the nuclear age. The first part is dedicated to the role the Alliance played in the arms-control and non-proliferation process that shaped the ...
Nuti, Leopoldo
core  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

No First Use and Credible Deterrence

open access: yesJournal for Peace and Nuclear Disarmament, 2018
Despite progress in reducing the number of nuclear weapons in the largest arsenals, a number of states are now looking to increase their reliance on nuclear weapons not only for deterrence, but also for coercion or war fighting.
Steve Fetter, Jon Wolfsthal
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Enhancing traffic flow prediction through multi-view attention mechanism and dilated convolutional networks

open access: yesComplex & Intelligent Systems
Accurate traffic flow forecasting serves as a cornerstone for intelligent transportation systems, enabling proactive accident prevention and metropolitan mobility optimization.
Wei Li   +6 more
doaj   +1 more source

Promoting Nuclear Disarmament through Bilateral Arms Control: Will New START Extension Pave the Path to Disarmament?

open access: yesJournal for Peace and Nuclear Disarmament, 2021
The United States and Russia agreed to extend the 2010 New START Treaty in February 2021. Many analysts believed that this step would reinvigorate the US-Russian arms control process, lead to deeper reductions in nuclear weapons, and possibly pave the ...
Amy F. Woolf
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Behavioral Arms Control and East Asia

open access: yesJournal for Peace and Nuclear Disarmament
Growing political and military tensions between China and the United States make it necessary to think of novel arms control approaches on nuclear weapons and certain emerging technologies, designed to include China and other actors.
Ulrich Kühn, Heather Williams
doaj   +1 more source

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