Results 51 to 60 of about 1,301,095 (294)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Reevaluating Conventional Strategies: Harnessing Traditional Structures to Counter Violent Extremism in Pakistan

NUST Journal of International Peace and Stability
Civil-military relations constitute a complex area of international relations through the interaction of military institutions, civil society, and other governmental bureaucracies.
Sardar Jehanzaib Ghalib
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

No First Use and Credible Deterrence

Journal for Peace and Nuclear Disarmament, 2018
Despite progress in reducing the number of nuclear weapons in the largest arsenals, a number of states are now looking to increase their reliance on nuclear weapons not only for deterrence, but also for coercion or war fighting.
Steve Fetter, Jon Wolfsthal
doaj   +1 more source

Keys to unblocking multilateral nuclear arms control [PDF]

, 2002
Includes bibliographical references (p. 9.) "July 2002"This article outlines the activities that must be undertaken and the issues that must be addressed in order for multilateral arms control to succeed in the 21st century, given the current US ...
Sands, Amy, Singer, Clifford E.
core  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Guterres Disarmament Agenda and the Challenge of Constructing a Global Regime for Weapons

Journal for Peace and Nuclear Disarmament, 2020
On 24 May 2018, United Nations Secretary-General António Guterres launched his new “disarmament agenda” in an address at the University of Geneva.
Randy Rydell
doaj   +1 more source

Paper Tiger with Whitened Teeth [PDF]

, 2006
"The authors, Keir Lieber and Daryl Pres, mistakenly link preventive capability in peacetime to coercive power in crisis." Li Bin is the Director of the Arms Control Program and Professor of the Institute of International Studies at Tsinghua ...
Li Bin
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Enhancing traffic flow prediction through multi-view attention mechanism and dilated convolutional networks

Complex & Intelligent Systems
Accurate traffic flow forecasting serves as a cornerstone for intelligent transportation systems, enabling proactive accident prevention and metropolitan mobility optimization.
Wei Li, Hao Wei, Xin Liu, Jialin Liu, Dazhi Zhan, Xiao Han, Wei Tao   +6 more
doaj   +1 more source