Results 51 to 60 of about 369,690 (257)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Designing Conventional Arms Control Agreements

Scandinavian Journal of Military Studies
What determines the scope of conventional arms control (CAC) agreements in Europe? The crafting of an agreement can have important implications for the stability and trajectory of future relations while reflecting adversaries’ existing political and ...
William Lippert
doaj   +1 more source

Opposing the Strategic Arms Reduction Treaty in the U.S. Congress: Ideological analysis of Senate Armed Services and Foreign Relations Committee Hearings

American Studies in Scandinavia, 2019
The United States Senate voted to ratify the New Strategic Arms Reduction Treaty with Russia in 2010 by 74-26, all 26 voting against being Republicans.
Teemu Mäkinen
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Occupational health and safety regulations in China: development process, enforcement challenges, and solutions

Frontiers in Public Health
BackgroundOccupational health is closely related to China’s public health system and the construction of a healthy China. The purpose of this paper is to summarize the current health status of China’s occupational population and the dilemmas faced by ...
Xinyu Xu, Xinyu Xu, Xinyu Xu, Peihua Ren, Peihua Ren, Wenyan Shi, Wenyan Shi, Feidan Deng, Feidan Deng, Qingfeng Wang, Qingfeng Wang, Shaoteng Shi, Shaoteng Shi, Jingchun Shen, Jingchun Shen, Guoqiang Dong, Jing Han, Jing Han, Jing Han, Jing Han   +19 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Crisis in arms control: an introduction. [PDF]

Z Friedens Konfliktforsch, 2021
Wisotzki S, Kühn U.
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Is the NPT Still Relevant? – How to Progress the NPT’s Disarmament Provisions

Journal for Peace and Nuclear Disarmament, 2019
The Nuclear Non-Proliferation Treaty is the cornerstone of the global non-proliferation regime. However, the question is the NPT still relevant? may suggest that the importance of NPT has been forgotten.
John Carlson
doaj   +1 more source