Results 41 to 50 of about 398,162 (307)
Baltic Journal of Law & Politics, 2020 Despite being a crucially important domain for states, businesses, and individuals, cyberspace still suffers from a regulation deficit. This article takes up one such dangerously underregulated area: cyber warfare and regulation of cyber weapons.
Kalpokienė Julija, Kalpokas Ignas
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Strategic Stability: Dynamics and Factors of Transformation
Вестник Московского Университета. Серия XXV: Международные отношения и мировая политика, 2023 The paper provides a comparative analysis study of the dynamics and mechanisms of the strategic stability transformation both during the Cold War and at present.
K. V. Bogdanov
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Distributed impedance control of coordinated dissimilar upper-limb exoskeleton arms
, 2023 Upper-limb exoskeleton (ULE) arms have emerged as promising wearable robotic devices for assisting humans in accomplishing tasks by distributing heavy loads.
Mattila, Jouni +1 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Journal for Peace and Nuclear Disarmament, 2019 On the way to a new world order we do not yet know, disorder is the new normal. The world is in a state of flux. Six features are particularly noteworthy. (1) Sovereign states are reemphasized and reconfirmed as the basic building blocks of international
Sverre Lodgaard
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Arms control policy of the People's Republic of China, 1949-1978
, 1985 This study investigates how the PRC, during the three decades since its establishment, has responded to international politics involving arms control and disarmament (ACD) issues, and explores the essence of China's approach to concepts of arms control ...
Hu, Zhiqiang
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
NUST Journal of International Peace and StabilityCivil-military relations constitute a complex area of international relations through the interaction of military institutions, civil society, and other governmental bureaucracies.
Sardar Jehanzaib Ghalib
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