Results 41 to 50 of about 1,301,095 (294)

Contemplating a Cyber Weapons Convention: An Exploration of Good Practice and Necessary Preconditions

open access: yesBaltic Journal of Law & Politics, 2020
Despite being a crucially important domain for states, businesses, and individuals, cyberspace still suffers from a regulation deficit. This article takes up one such dangerously underregulated area: cyber warfare and regulation of cyber weapons.
Kalpokienė Julija, Kalpokas Ignas
doaj   +1 more source

Constitutional Bait and Switch: Executive Reinterpretation of Arms Control Treaties [PDF]

open access: yes, 1989
A new constitutional crisis has been thrust upon the American body politic. The crisis arises from a dispute concerning the allocation of legal authority for the interpretation, and especially for the reinterpretation, of international agreements. Once a
Koplow, David A
core   +2 more sources

Heterodyne Holography with full control of both signal and reference arms

open access: yes, 2015
Heterodyne holography is a variant of phase shifting holography in which reference and signal arms are controlled by acousto optic modulators. In this review paper, we will briefy describe the method and its properties, and we will illustrate its ...
Gross, Michel
core   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Arms Control and World Order

open access: yesJournal for Peace and Nuclear Disarmament, 2019
On the way to a new world order we do not yet know, disorder is the new normal. The world is in a state of flux. Six features are particularly noteworthy. (1) Sovereign states are reemphasized and reconfirmed as the basic building blocks of international
Sverre Lodgaard
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Asymmetric Mach-Zehnder fiber interferometer test of the anisotropy of the speed of light

open access: yes, 2009
Two optical fiber Mach-Zehnder interferometers were constructed in an environment with a temperature stabilization of better than 1 mK per day. One interferometer with a length of 2 m optical fiber in each arm with the main direction of the arms parallel
Cahill R.T.   +8 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

The new nuclear arms control environment : trip report and project conclusions [PDF]

open access: yes, 2002
Includes bibliographical references. "July 2002"This paper reports the results of 9 conference, workshops and private meetings held on the current diplomatic and security problems associated with nuclear arms control, both before and after September 11 ...
Gottemoeller, Rose   +3 more
core  

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