Results 1 to 10 of about 35,132 (248)

The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

Frontiers in Pharmacology, 2021
Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants.
Yue Liu, Chengniu Wang, Bo Jiang
exaly   +3 more sources

Characterization of SARS-CoV-2 Evasion: Interferon Pathway and Therapeutic Options

Viruses, 2022
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to circumvent the innate immune response. The early interferon (IFN) response is necessary
Mariem Znaidia, Caroline Demeret, Sylvie van der Werf, Anastassia V. Komarova   +3 more
doaj   +1 more source

مطالعۀ فنوتیپی و ژنوتیپی کلاس‌های ژن تنظیم‌گر مقاومت به کولیستین (arn) در اسینتوباکتر بومانی جداشده از موارد بالینی به روش PCR چندگانه [PDF]

Biological Journal of Microorganism, 2020
مقدمه: کولیستین آخرین خط درمان در عفونت‌های بیمارستانی ناشی از اسینتوباکتر بومانی به شمار می‌آید. امروزه با روشن‌شدن سازوکار انتقال مقاومت از طریق ژن‌های arn، بروز الگوی مقاومت دارویی جدید در جدایه‌‏های اسینتوباکتر بومانی مشاهده شده است.
فرنوش کریمی, کیومرث امینی, غلامرضا جوادی   +2 more
doaj   +1 more source

Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases

mBio, 2020
The multifunctional nature of viral proteins is essentially driven by posttranslational modifications (PTMs) and is key for the successful outcome of infection.
Marwah Karim, Elise Biquand, Marion Declercq, Yves Jacob, Sylvie van der Werf, Caroline Demeret   +5 more
doaj   +1 more source

Viral Retinitis: Review

Delhi Journal of Ophthalmology, 2021
Retinitis is one of the common presentation of posterior uveitis. The cause could be either an infection or inflammation but until proven otherwise, retinitis is infectious.
Anamika Patel, Mudit Tyagi
doaj   +1 more source

Los trastornos neurocognitivos y retos de la epigenética

Biociencias, 2022
Introducción: Los Trastornos neurocognitivos se definen como un conjunto de anomalías en la capacidad del aprendizaje y la memoria de un individuo. En múltiples estudios se han encontrado variados marcadores genéticos que están emergiendo a raíz de la ...
Juan David Marenco Salazar, José María Mejía Barrera, Javier Alfredo Pérez Martínez, Said Samir Sánchez Salcedo, Alfredo Pugliese Jiménez   +4 more
doaj   +1 more source

Neuropsychiatric or Behavioral and Psychological Symptoms of Dementia (BPSD): Focus on Prevalence and Natural History in Alzheimer's Disease and Frontotemporal Dementia

Frontiers in Neurology, 2022
Neuropsychiatric or behavioral and psychological symptoms of dementia (BPSD) represent a heterogeneous group of non-cognitive symptoms that are virtually present in all patients during the course of their disease.
Valentina Laganà, Francesco Bruno, Francesco Bruno, Natalia Altomari, Giulia Bruni, Nicoletta Smirne, Sabrina Curcio, Maria Mirabelli, Rosanna Colao, Gianfranco Puccio, Francesca Frangipane, Chiara Cupidi, Giusy Torchia, Gabriella Muraca, Antonio Malvaso, Desirèe Addesi, Desirèe Addesi, Alberto Montesanto, Raffaele Di Lorenzo, Raffaele Di Lorenzo, Amalia Cecilia Bruni, Raffaele Maletta   +21 more
doaj   +1 more source

Detection and Quantification of Influenza Virus Defective Viral Genomes from NGS Datasets Obtained after RT or RT-PCR Product Sequencing

Proceedings, 2020
Like most RNA viruses, influenza viruses (IAV) generate defective viral genomes (DVGs) during viral replication. Although there is accumulating evidence of a biological impact of DVGs, the molecular mechanisms leading to their production remain to be ...
Jeremy Boussier, Sandie Munier, Bernadette Crescenzo-Chaigne, Sylvie Behillil, Vincent Enouf, Sylvie van der Werf, Nadia Naffakh   +6 more
doaj   +1 more source

Alternative Transcription Start Site Usage and Functional Implications in Pathogenic Fungi

Journal of Fungi, 2022
Pathogenic fungi require delicate gene regulation mechanisms to adapt to diverse living environments and escape host immune systems. Recent advances in sequencing technology have exposed the complexity of the fungal genome, thus allowing the gradual ...
Thi Tuong Vi Dang, Jessie Colin, Guilhem Janbon   +2 more
doaj   +1 more source

Influenza B Virus Infection Is Enhanced Upon Heterotypic Co-infection With Influenza A Virus

Frontiers in Microbiology, 2021
Homotypic co-infections with influenza viruses are described to increase genetic population diversity, to drive viral evolution and to allow genetic complementation. Less is known about heterotypic co-infections between influenza A (IAV) and influenza B (
Nicolas Malausse, Nicolas Malausse, Sylvie van der Werf, Nadia Naffakh, Sandie Munier   +4 more
doaj   +1 more source