Results 11 to 20 of about 204,600 (222)

Independent and joint effects of body mass index and metabolic health in mid- and late-life on all-cause mortality: a cohort study from the Swedish Twin Registry with a mean follow-up of 13 Years

BMC Public Health, 2022
Background There is robust evidence that in midlife, higher body mass index (BMI) and metabolic syndrome (MetS), which often co-exist, are associated with increased mortality risk.
Peggy Ler, Xia Li, Linda B. Hassing, Chandra A. Reynolds, Deborah Finkel, Ida K. Karlsson, Anna K. Dahl Aslan   +6 more
doaj   +1 more source

Trehalose-Based Nucleolipids as Nanocarriers for Autophagy Modulation: An In Vitro Study

Pharmaceutics, 2022
The Autophagy Lysosomal Pathway is one of the most important mechanisms for removing dysfunctional cellular components. Increasing evidence suggests that alterations in this pathway play a pathogenic role in Parkinson’s disease, making it a point of ...
Anthony Cunha, Alexandra Gaubert, Julien Verget, Marie-Laure Thiolat, Philippe Barthélémy, Laurent Latxague, Benjamin Dehay   +6 more
doaj   +1 more source

Detection and Quantification of Influenza Virus Defective Viral Genomes from NGS Datasets Obtained after RT or RT-PCR Product Sequencing

Proceedings, 2020
Like most RNA viruses, influenza viruses (IAV) generate defective viral genomes (DVGs) during viral replication. Although there is accumulating evidence of a biological impact of DVGs, the molecular mechanisms leading to their production remain to be ...
Jeremy Boussier, Sandie Munier, Bernadette Crescenzo-Chaigne, Sylvie Behillil, Vincent Enouf, Sylvie van der Werf, Nadia Naffakh   +6 more
doaj   +1 more source

Identifying vital edges in Chinese air route network via memetic algorithm [PDF]

, 2016
Due to its rapid development in the past decade, air transportation system has attracted considerable research attention from diverse communities.
Cao, Xian-Bin, Du, Wen-Bo, Liang, Bo-Yuan, Lordan, Oriol, Yan, Gang   +4 more
core   +4 more sources

Affine image registration of arterial spin labeling MRI using deep learning networks

NeuroImage, 2023
Convolutional neural networks (CNN) have demonstrated good accuracy and speed in spatially registering high signal-to-noise ratio (SNR) structural magnetic resonance imaging (sMRI) images. However, some functional magnetic resonance imaging (fMRI) images,
Zongpai Zhang, Huiyuan Yang, Yanchen Guo, Nicolas R. Bolo, Matcheri Keshavan, Eve DeRosa, Adam K. Anderson, David C. Alsop, Lijun Yin, Weiying Dai   +9 more
doaj   +1 more source

Diseño de tres pares de oligonucleótidos específicos para la detección del virus de la mancha anular de la papaya (PRSV)

RIA: Revista Investigaciones Agropecuarias, 2022
Por un lado, en México, el estado de Oaxaca ha ocupado en años consecutivos los primeros lugares a nivel nacional en la producción de papaya (Carica papaya L.).
J.K. Cruz, J. Ochoa, V. Ortega, Francisco G. Ruiz   +3 more
doaj  

Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis. [PDF]

, 2017
In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the ...
Barakat, Rita, Brooks, George A, Efe, Gizem, Garan, Steven A, Gouw, Arvin M, Mehdizadeh, Morvarid, Preecha, Andrew   +6 more
core   +1 more source

Síndrome frágil X

Medimay, 2014
Se realiza una revisión actualizada sobre las peculiaridades clínicas fenotípicas, citogenéticas, diagnosticas y de pesquisaje del Síndrome frágil X o de Martín Bell, una de las enfermedades monogénicas mas frecuentes en el ser humano y causa más común ...
Jesús Pérez Ramas
doaj   +4 more sources

The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

Frontiers in Pharmacology, 2021
Depression is a widespread chronic medical illness affecting thoughts, mood, and physical health. However, the limited and delayed therapeutic efficacy of monoaminergic drugs has led to intensive research efforts to develop novel antidepressants.
Yue Liu, Yue Liu, Wenqian Tang, Wenqian Tang, Chunhui Ji, Chunhui Ji, Jianghong Gu, Jianghong Gu, Yanmei Chen, Yanmei Chen, Jie Huang, Jie Huang, Xinyi Zhao, Yingfang Sun, Chengniu Wang, Wei Guan, Wei Guan, Jianfeng Liu, Bo Jiang, Bo Jiang   +19 more
doaj   +1 more source

The Role of the Brain in the Pathogenesis and Physiology of Polycystic Ovary Syndrome (PCOS). [PDF]

, 2019
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting at least 10% of women of reproductive age. PCOS is typically characterized by the presence of at least two of the three cardinal features of hyperandrogenemia (high ...
Coutinho, Eulalia A, Kauffman, Alexander S   +1 more
core   +1 more source