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<i>PyCycleBio</i>: modelling non-sinusoidal-oscillator systems in temporal biology. [PDF]

Bioinform Adv
Bennett AR, Birchenough G, Bojar D.
europepmc   +1 more source

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The circadian clock gene ARNTL regulates the expression of CCR6 and Th17 related genes in human cells

Journal of Immunology, 2022
Previously we have shown that CCR6 expression uniquely defines a major branch of the Th effector/memory population that includes cells with both Th17 and Th17-associated phenotypes, therefore, studying the regulation of CCR6 will reveal molecular ...
S. Singh, Farhat Parween, Nithin Edara, Hongwei H Zhang, Paul J. Gardina, Francisco A. Otaizo-Carrasquero, T. Myers, J. Farber   +7 more
semanticscholar   +1 more source

Transcription factors in the development and treatment of immune disorders

Transcription, 2023
Immune function is highly controlled at the transcriptional level by the binding of transcription factors (TFs) to promoter and enhancer elements. Several TF families play major roles in immune gene expression, including NF-κB, STAT, IRF, AP-1, NRs, and ...
Samantha D Patalano, Paula Fuxman Bass, J. F. Fuxman Bass   +2 more
semanticscholar   +1 more source

Targeting bacterial transcription factors for infection control: opportunities and challenges

Transcription, 2023
The rising threat of antibiotic resistance in pathogenic bacteria emphasizes the need for new therapeutic strategies. This review focuses on bacterial transcription factors (TFs), which play crucial roles in bacterial pathogenesis.
Ahmed Al-Tohamy, A. Grove
semanticscholar   +1 more source

Transcription factors TP63 facilitates malignant progression of thyroid cancer by upregulating KRT17 expression and inducing epithelial-mesenchymal transition

Growth Factors, 2023
Thyroid cancer (TC) is a relatively prevalent endocrine tumor among women, the incidence of which is rapidly rising. In this present study, we aimed to provide new therapeutic targets from the aspect of transcription factor-target gene interaction.
Fanbo Meng, Liting Dai
semanticscholar   +1 more source

BMAL1 Links Bevacizumab Resistance in Colorectal Cancer to Circadian Rhythm and Heme Receptor REVERBA

Social Science Research Network, 2019
Heme sensor Nuclear Receptor Subfamily 1 Group D Member 1 (NR1D1/REVERBA) and its target gene Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL/BMAL1) regulate circadian rhythm and angiogenesis.
E. Burgermeister, F. Battaglin, F. Eladly, Wen Wu, F. Herweck, Nadine Schulte, J. Betge, N. Härtel, Jakob Nikolas Kather, Cleo-Aron Weis, T. Gaiser, A. Marx, C. Weiss, R. Hofheinz, Ian S. Miller, F. Loupakis, H. Lenz, A. Byrne, M. Ebert   +18 more
semanticscholar   +1 more source

Circadian Rhythm, Hypoxia, and Cellular Senescence: From Molecular Mechanisms to Targeted Strategies.

European Journal of Pharmacology
Cellular senescence precipitates a decline in physiological activities and metabolic functions, often accompanied by heightened inflammatory responses, diminished immune function, and impaired tissue and organ performance. Despite extensive research, the
Tong Nie, E. Nepovimova, Qinghua Wu
semanticscholar   +1 more source

Decoding complexity: tackling the challenge of how many transcription factors regulate a plant gene

Transcription
The regulation of transcription is a major control point in the flow of information from the genome to the phenome. Central to this regulation are transcription factors (TFs), which bind specific DNA motifs in gene regulatory regions.
John Gray, E. Grotewold
semanticscholar   +1 more source

Orphan nuclear receptor transcription factors as drug targets

Transcription
The nuclear receptor (NR) superfamily of ligand-activated receptors plays a key role in maintaining cellular homeostasis and in pathophysiology. NRs can be subdivided into functional activities structural similarity and the existence of endogenous ...
Stephen Safe, A. R. Oany, Wai Ning Tiffany Tsui, Miok Lee, Vinod Srivastava, Srijana Upadhyay, Amanuel Hailemariam, Evan Farkas, Sarah Kakwan, Caitrina Kearns, Gargi Sivaram   +10 more
semanticscholar   +1 more source

Hypoxia-inducible transcription factors: architects of tumorigenesis and targets for anticancer drug discovery

Transcription
Hypoxia-inducible factors (HIFs) play a pivotal role as master regulators of tumor survival and growth, controlling a wide array of cellular processes in response to hypoxic stress.
Alexander McDermott, Ali Tavassoli
semanticscholar   +1 more source