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The neurobiology of circadian rhythms [PDF]

Current Opinion in Pulmonary Medicine, 2009
There is growing awareness of the importance of circadian rhythmicity in various research fields. Exciting developments are ongoing in the field of circadian neurobiology linked to sleep, food intake, and memory. With the current knowledge of critical 'clock genes' (genes found to be involved in the generation of circadian rhythms) and novel techniques
Eddy A, Van der Zee, Gretha J, Boersma, Roelof A, Hut   +2 more
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Reduced expression of the PER2 protein contributes to β₁-AA-induced cardiac autophagy rhythm disorders

Acta Biochimica et Biophysica Sinica
Heart failure may be linked to fluctuations in the rhythm of autophagy in cardiomyocytes throughout the day. Circadian rhythms depend on the regulation of core biological clock proteins, with PER2 playing a crucial role.
Li Pengjia, Feng Jiayan, Guo Jiao, Xue Jin, Li Yang, Wen Shiyuan, Wang Xiaohui, Liu Huirong, Wang Li   +8 more
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Rheostatic Balance of Circadian Rhythm and Autophagy in Metabolism and Disease

Frontiers in Cell and Developmental Biology, 2020
Circadian rhythms are physical, behavioral and environmental cycles that respond primarily to light and dark, with a period of time of approximately 24 h.
Xiang Wang, Zhijie Xu, Yuan Cai, Shuangshuang Zeng, Bi Peng, Xinxin Ren, Yuanliang Yan, Zhicheng Gong, Zhicheng Gong   +8 more
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Deciphering Lipid Metabolic Landscape of Sorafenib-Treated Hepatocellular Carcinoma by Mass Spectrometry Imaging and Transcriptomics

Biomolecules
Although sorafenib (SOR) is effective for advanced hepatocellular carcinoma (HCC), significant metabolic heterogeneity limits its therapeutic effect. In this study, we employed high-resolution matrix-assisted laser desorption/ionization mass spectrometry
Dongsheng Li, Yuanyuan Tuo, Luheng Sai, Xiunan Xu, Fujuan Peng, Zhipeng Yan, Qin Yang, Huifang Zhao, Ruiping Zhang   +8 more
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Genetics of Circadian Rhythms

Neurologic Clinics, 2019
In mammals, genetic influences of circadian rhythms occur at many levels. A set of core "clock genes" have been identified that form a feedback loop of gene transcription and translation. The core genetic clockwork generates circadian rhythms in cells throughout the body.
Martha Hotz, Vitaterna, Kazuhiro, Shimomura, Peng, Jiang   +2 more
openaire   +3 more sources

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

Journal of Hematology & Oncology, 2022
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity–rest cycles, coordinating the behavior and physiology of all organs for ...
Li Zhou, Zhe Zhang, Edouard Nice, Canhua Huang, Wei Zhang, Yong Tang   +5 more
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Smartphone Sensor Data for Identifying and Monitoring Symptoms of Mood Disorders: A Longitudinal Observational Study

JMIR Mental Health, 2022
BackgroundMood disorders are burdensome illnesses that often go undetected and untreated. Sensor technologies within smartphones may provide an opportunity for identifying the early changes in circadian rhythm and social support ...
Taylor A Braund, May The Zin, Tjeerd W Boonstra, Quincy J J Wong, Mark E Larsen, Helen Christensen, Gabriel Tillman, Bridianne O’Dea   +7 more
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Circadian rhythms in parasites

PLOS Pathogens, 2017
Copyright: © 2017 Rijo-Ferreira et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Filipa Rijo-Ferreira, Joseph S. Takahashi, Luisa M. Figueiredo   +2 more
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Chronobiology and Mood Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2011
Living organizms show cyclic rhythmicity in a variety of physiological, hormonal, behavioral, and psychological processes. Sleep-wake cycles, body temperature, hormone levels, mood and cognition display a circadian rhythm in humans.
Yavuz Selvi, Lutfullah Besiroglu, Adem Aydin   +2 more
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Mucosal circadian rhythm pathway genes altered by aging and periodontitis

PLoS ONE, 2022
As circadian processes can impact the immune system and are affected by infections and inflammation, this study examined the expression of circadian rhythm genes in periodontitis.
Jeffrey L. Ebersole, Octavio A. Gonzalez
doaj   +2 more sources