Metformin Regulation of the Liver Circadian Clock and Metabolic Aging: A Systems Modeling Study [PDF]
MetabolitesIntroduction: Aging affects both metabolic and circadian systems, leading to disruptions in energy homeostasis and phase shifts in the circadian clock. Metformin, a widely used antihyperglycemic drug, exerts anti-aging effects by modulating key pathways ...
Mengyuan Zhang, Ying Li
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Mood phenotypes in rodent models with circadian disturbances
Neurobiology of Sleep and Circadian Rhythms, 2022 Many physiological functions with approximately 24-h rhythmicity (circadian rhythms) are generated by an internal time-measuring system of the circadian clock.
Kiyomichi Imamura, Toru Takumi
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Circadian clock—A promising scientific target in oral science
Frontiers in Physiology, 2022 The oral and maxillofacial organs play vital roles in chewing, maintaining facial beauty, and speaking. Almost all physiological processes display circadian rhythms that are driven by the circadian clock, allowing organisms to adapt to the changing ...
Guangxia Feng +16 more
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Circadian clock: a regulator of the immunity in cancer
Cell Communication and Signaling, 2021 The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various genes.
Zhen Zhang +5 more
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Silybin A enhances circadian clock by targeting CRY1 and disrupting its interaction with CLOCK
Pharmacological Research - Modern Chinese Medicine, 2022 Circadian clock governs a large array of physiological and metabolic functions. The amplitude decline of circadian rhythm is associated with various chronic diseases. However, few clock enhancing-molecules are known. CRY1 is one of the main components of
Weijie Bian +4 more
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Tuning up an aged clock: Circadian clock regulation in metabolism and aging
Translational Medicine of Aging, 2022 Circadian rhythms provide temporal variation of a broad range of behavioral and physiological functions, which is precisely controlled by the internal molecular gear, the circadian clock.
Shogo Sato +3 more
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Circadian Rhythms in the CNS and Peripheral Clock Disorders: The Circadian Clock and Hyperlipidemia
Journal of Pharmacological Sciences, 2007 A circadian clock controls various physiological and behavioral rhythms. In mammals, a master circadian clock exists in the suprachiasmatic nucleus of the hypothalamus, and slave oscillators can be found in most tissues.
Takashi Kudo +2 more
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Parallel analysis of Arabidopsis circadian clock mutants reveals different scales of transcriptome and proteome regulation [PDF]
Open Biology, 2017 The circadian clock regulates physiological processes central to growth and survival. To date, most plant circadian clock studies have relied on diurnal transcriptome changes to elucidate molecular connections between the circadian clock and observable ...
Alexander Graf +6 more
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Crosstalk between the circadian clock and innate immunity in Arabidopsis. [PDF]
PLoS Pathogens, 2013 The circadian clock integrates temporal information with environmental cues in regulating plant development and physiology. Recently, the circadian clock has been shown to affect plant responses to biotic cues.
Chong Zhang +10 more
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Neoplasia: An International Journal for Oncology Research, 2015 Clock circadian regulator (CLOCK)/brain and muscle arnt-like protein-1 (BMAL1) complex governs the regulation of circadian rhythm through triggering periodic alterations of gene expression.
Ming Cui +5 more
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