Results 21 to 30 of about 372,746 (304)
Trends in Pharmacological Sciences, 2018 Daily rhythms in behavior, physiology, and metabolism are an integral part of homeostasis. These rhythms emerge from interactions among endogenous circadian clocks, ambient light-dark-, sleep-activity-, and eating-fasting cycles.
Emily Nicole Manoogian +2 more
exaly +2 more sources
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The molecular clock provides an anticipatory mechanism, allowing organisms to prepare and respond to daily changes in the external environment.
James Early +2 more
exaly +2 more sources
Circadian Clock, Cell Division, and Cancer: From Molecules to Organism
International Journal of Molecular Sciences, 2017 As a response to environmental changes driven by the Earth’s axial rotation, most organisms evolved an internal biological timer—the so called circadian clock—which regulates physiology and behavior in a rhythmic fashion.
Anton Shostak
exaly +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance The circadian clock modulates the expression of many protein-coding genes in most cell types, thereby playing a key role in human health. Recent discoveries have unveiled the circadian clock as a novel pathway for therapeutic intervention in
Meng Qu +10 more
semanticscholar +1 more source
Mood phenotypes in rodent models with circadian disturbances
Neurobiology of Sleep and Circadian Rhythms, 2022 Many physiological functions with approximately 24-h rhythmicity (circadian rhythms) are generated by an internal time-measuring system of the circadian clock.
Kiyomichi Imamura, Toru Takumi
doaj +1 more source
The cyanobacterial circadian clock. [PDF]
NPJ Biol Timing SleepThis review summarizes recent advances in understanding the cyanobacterial circadian clock, emphasizing how the KaiA, KaiB, and KaiC proteins generate robust, temperature-compensated rhythms through ordered phosphorylation, conformational switching, and dynamic protein interactions. A comparative analysis of 30 KaiC structures under different states of
Chang YG, LiWang A.
europepmc +3 more sources
Circadian Clocks: Evolution in the Shadows [PDF]
Current Biology, 2009 As scientists, we strive for highly controlled conditions. The real world, however, is noisy. Complex networks are a coping mechanism for an erratic environment.
Merrow, Martha, Maas, Marc F. P. M.
openaire +3 more sources
Circadian Biology: Clocks within Clocks [PDF]
Current Biology, 2005 A small cluster of approximately 20,000 neurons in the ventral hypothalamus provide the body with key time-keeping signals and drive circadian rhythms. This circadian clock exhibits surprisingly complex substructures, with inputs from the retina, and outputs to other brain structures.
Piggins, Hugh D. +1 more
openaire +2 more sources
The Circadian Clock in Lepidoptera [PDF]
Frontiers in Physiology, 2021 With approximately 160,000 identified species of butterflies and moths, Lepidoptera are among the most species-rich and diverse insect orders. Lepidopteran insects have fundamental ecosystem functions as pollinators and valuable food sources for countless animals.
Brady D. +3 more
openaire +4 more sources
The Plant Cell, 2020 The rice circadian clock integrates sugar signaling and regulates expression of strigolactone pathway genes to control tillering and panicle development.
F. Wang +7 more
semanticscholar +1 more source