Results 21 to 30 of about 369,771 (309)
Molecular mechanism of the repressive phase of the mammalian circadian clock
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance The circadian clock mechanism is a daily rhythmic activation of circadian gene transcription by the CLOCK–BMAL1 heterodimer and repression by CRYs (CRY1 and CRY2) and PERs (PER1 and PER2).
Xuemei Cao +4 more
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Nutrients, 2023 Rhythmicity is a fundamental characteristic of every living organism [...]
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Molecular Links between the Circadian Clock and the Cell Cycle.
Journal of Molecular Biology, 2020 Circadian control of cell division is well established in diverse organisms. Recent single cell studies on mouse fibroblasts have shown that the circadian clock and cell cycle systems are robustly phase-coupled in a bidirectional manner. In healthy cells,
Elham Farshadi +2 more
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Circadian Rhythm, Clock Genes and Hypertension: Recent Advances in Hypertension
HYPERTENSION, 2021 Accumulating evidence suggests that the molecular circadian clock is crucial in blood pressure (BP) control. Circadian rhythms are controlled by the central clock, which resides in the suprachiasmatic nucleus of the hypothalamus and peripheral clocks ...
Hannah M. Costello, Michelle L. Gumz
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Molecular Interactions Between Components of the Circadian Clock and the Immune System
Journal of Molecular Biology, 2020 The immune system is under control of the circadian clock. Many of the circadian rhythms observed in the immune system originate in direct interactions between components of the circadian clock and components of the immune system.
S. Hergenhan +2 more
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Neurobiology of Disease, 2020 A substantial body of research now implicates the circadian clock in the regulation of an array of diverse biological processes including glial function, metabolism, peripheral immune responses, and redox homeostasis.
Brian V. Lananna, E. Musiek
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Circadian Clocks and Pregnancy [PDF]
Frontiers in Endocrinology, 2014 The recognition that 24-h rhythmic processes (“circadian”) underlie many endocrine functions has added a fascinating new temporal dimension to our appreciation of their complexity. Research from various laboratories has revealed circadian gene expression in multiple tissues in the reproductive system of non-pregnant and pregnant mammals.
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Circadian-Clock Regulation on Lipid Metabolism and Metabolic Diseases
Advances in Experimental Medicine and Biology, 2020 The basic helix-loop-helix-PAS transcription factor (CLOCK, Circadian Locomoter Output Cycles Protein Kaput) was discovered in 1994 as a circadian clock.
Xiaoyue Pan, Samantha Mota, Boyang Zhang
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NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1
bioRxiv, 2020 In mammals, the circadian clock coordinates various cell physiological processes, including the inflammatory response. Recent studies suggested a crosstalk between these two pathways. However, the mechanism of how inflammation affects the circadian clock
Yang Shen +10 more
semanticscholar +1 more source
Circadian clocks in the ovary [PDF]
Trends in Endocrinology & Metabolism, 2010 Clock gene expression has been observed in tissues of the hypothalamic-pituitary-gonadal (HPG) axis. Whereas the contribution of hypothalamic oscillators to the timing of reproductive biology is well known, the role of peripheral oscillators like those in the ovary is less clear.
Michael T, Sellix, Michael, Menaker
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