Results 11 to 20 of about 372,746 (304)
Circadian clock: a regulator of the immunity in cancer
Cell Communication and Signaling, 2021 The circadian clock is an endogenous timekeeper system that controls and optimizes biological processes, which are consistent with a master circadian clock and peripheral clocks and are controlled by various genes.
Zhen Zhang +5 more
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Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment
Trends in Cancer, 2019 Circadian clocks are evolutionary molecular machinery that dictate temporal regulation of physiology to maintain homeostasis. Disruption of circadian rhythm plays a key role in tumorigenesis and facilitates the establishment of cancer hallmarks ...
Michael Tun Yin Lam +1 more
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Transcriptional architecture of the mammalian circadian clock
Nature Reviews Genetics, 2016 Circadian clocks are endogenous oscillators that control 24-hour physiological and behavioural processes in organisms. These cell-autonomous clocks are composed of a transcription–translation-based autoregulatory feedback loop.
Joseph S Takahashi, Takahashi Joseph S
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Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion
Frontiers in Immunology, 2019 Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved.
Yingcheng Wu +6 more
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Cancer and the Circadian Clock
Cancer Research, 2019 The circadian clock is a master regulator of mammalian physiology, regulating daily oscillations of crucial biological processes and behaviors. Notably, circadian disruption has recently been identified as an independent risk factor for cancer and ...
Ayesha A. Shafi, K. Knudsen
semanticscholar +4 more sources
Defining the Independence of the Liver Circadian Clock
Cell, 2019 SUMMARY Mammals rely on a network of circadian clocks to control daily systemic metabolism and physiology. The central pacemaker in the suprachiasmatic nucleus (SCN) is considered hierarchically dominant over peripheral clocks, whose degree of ...
Jacob Smith +2 more
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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Cell, 2018 Summary: Recent reports ind icate hypoxia influences the circadian clock through the transcriptional activities of hypoxia inducible factors (HIFs) at clock genes.
Costas Koumenis +2 more
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Circadian clock regulation of hemostasis: a systematic review of molecular pathways [PDF]
Research and Practice in Thrombosis and HaemostasisThrombotic events such as myocardial infarction and stroke exhibit circadian variation with early-morning peaks, implicating intrinsic biological regulation, yet the molecular mechanisms coordinating hemostatic function remain unclear.
Zeinab Ibrahim +4 more
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Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder
Cell, 2017 SUMMARY Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes ~24 hour rhythms in many behavioral and physiological processes.
Tayfun Özçelik +2 more
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Metformin Regulation of the Liver Circadian Clock and Metabolic Aging: A Systems Modeling Study [PDF]
MetabolitesIntroduction: Aging affects both metabolic and circadian systems, leading to disruptions in energy homeostasis and phase shifts in the circadian clock. Metformin, a widely used antihyperglycemic drug, exerts anti-aging effects by modulating key pathways ...
Mengyuan Zhang, Ying Li
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