Novel mechanisms operating in the central pacemaker and in the light-synchronization pathway of Drosophila’s circadian clock [PDF]
, 2011 PhDMost organisms display circadian rhythms of approximately 24 hours in many aspects of their physiology and behaviour. The synchronization between their internal rhythm and the environmental light-dark cycles is essential for an organism’s survival ...
Chen, Ko-Fan
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Isolation of new genes involved in temperature synchronization of the circadian clock of Drosophila melanogaster [PDF]
, 2010 PhDCircadian clocks regulate behaviour and physiology of many organisms and keep them in synchrony with the environment. Drosophila's circadian clock is mainly synchronized by natural light-dark cycles and temperature fluctuations, both at molecular
Simoni, Alekos
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The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models [PDF]
, 2010 Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock.
Andrew J Millar +15 more
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Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle [PDF]
, 2015 The human hair follicle (HF) exhibits peripheral clock activity, with knock-down of clock genes (BMAL1 and PER1) prolonging active hair growth (anagen) and increasing pigmentation.
Haslam, Iain S. +16 more
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ELF4 is required for oscillatory properties of the circadian clock [PDF]
, 2007 Circadian clocks are required to coordinate metabolism and physiology with daily changes in the environment. Such clocks have several distinctive features, including a free-running rhythm of approximately 24 h and the ability to entrain to both light or ...
Nagy, Ferenc +22 more
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Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion
Frontiers in Immunology, 2019 Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved.
Yingcheng Wu +6 more
doaj +1 more source
Crosstalk between the circadian clock and innate immunity in Arabidopsis. [PDF]
PLoS Pathogens, 2013 The circadian clock integrates temporal information with environmental cues in regulating plant development and physiology. Recently, the circadian clock has been shown to affect plant responses to biotic cues.
Chong Zhang +10 more
doaj +1 more source
Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.
PLoS Genetics, 2012 The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues.
Michael E Hughes +7 more
doaj +1 more source
Circadian control of isoprene emissions from oil palm (Elaeis guineensis) [PDF]
, 2006 The emission of isoprene from the biosphere to the atmosphere has a profound effect on the Earth's atmospheric system. Until now, it has been assumed that the primary short-term controls on isoprene emission are photosynthetically active radiation and ...
Gould, Peter +7 more
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NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.
PLoS Genetics, 2016 Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN), the master circadian pacemaker, CLOCK-deficient mice ...
Dominic Landgraf +3 more
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