Results 11 to 20 of about 369,771 (309)
Cancer and the Circadian Clock.
Cancer Research, 2019 The circadian clock is a master regulator of mammalian physiology, regulating daily oscillations of crucial biological processes and behaviors. Notably, circadian disruption has recently been identified as an independent risk factor for cancer and ...
Ayesha A. Shafi, K. Knudsen
semanticscholar +4 more sources
Pan-Cancer Analysis Reveals Disrupted Circadian Clock Associates With T Cell Exhaustion
Frontiers in Immunology, 2019 Although dysfunctional circadian clock has emerged as a hallmark of cancer, fundamental gaps remain in our understanding of the underlying mechanisms involved.
Yingcheng Wu +6 more
doaj +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance The circadian clock modulates the expression of many protein-coding genes in most cell types, thereby playing a key role in human health. Recent discoveries have unveiled the circadian clock as a novel pathway for therapeutic intervention in
Meng Qu +10 more
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The cyanobacterial circadian clock. [PDF]
NPJ Biol Timing SleepThis review summarizes recent advances in understanding the cyanobacterial circadian clock, emphasizing how the KaiA, KaiB, and KaiC proteins generate robust, temperature-compensated rhythms through ordered phosphorylation, conformational switching, and dynamic protein interactions. A comparative analysis of 30 KaiC structures under different states of
Chang YG, LiWang A.
europepmc +3 more sources
Circadian Clocks: Evolution in the Shadows [PDF]
Current Biology, 2009 As scientists, we strive for highly controlled conditions. The real world, however, is noisy. Complex networks are a coping mechanism for an erratic environment.
Merrow, Martha, Maas, Marc F. P. M.
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Circadian Biology: Clocks within Clocks [PDF]
Current Biology, 2005 A small cluster of approximately 20,000 neurons in the ventral hypothalamus provide the body with key time-keeping signals and drive circadian rhythms. This circadian clock exhibits surprisingly complex substructures, with inputs from the retina, and outputs to other brain structures.
Piggins, Hugh D. +1 more
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The Circadian Clock in Lepidoptera [PDF]
Frontiers in Physiology, 2021 With approximately 160,000 identified species of butterflies and moths, Lepidoptera are among the most species-rich and diverse insect orders. Lepidopteran insects have fundamental ecosystem functions as pollinators and valuable food sources for countless animals.
Brady D. +3 more
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The circadian clock in mammals [PDF]
The Journal of Headache and Pain, 2000 The basic physiological and anatomical basis for circadian rhythms in mammalian behaviour and physiology is introduced. The pathways involved in photic entrainment of the circadian clock are discussed in relation of new findings that identify the molecules that are involved in signalling between the environment and the clock.
ZORDAN, MAURO AGOSTINO, KYRIACOU C. P.
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The Plant Cell, 2020 The rice circadian clock integrates sugar signaling and regulates expression of strigolactone pathway genes to control tillering and panicle development.
F. Wang +7 more
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Neurodegeneration and the Circadian Clock [PDF]
Frontiers in Aging Neuroscience, 2017 Despite varied etiologies and symptoms, several neurodegenerative diseases-specifically, Alzheimer's (AD), Parkinson's (PD), and Huntington's diseases (HDs)-share the common feature of abnormal circadian rhythms, such as those in behavior (e.g., disrupted sleep/wake cycles), physiological processes (e.g., diminished hormone release) and biochemical ...
Hood, Suzanne, Amir, Shimon
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