Results 31 to 40 of about 369,771 (309)
The circadian clock of cyanobacteria [PDF]
BioEssays, 2000 A circadian clock, with physiological characteristics similar to those of eukaryotes, functions in the photosynthetic prokaryote, cyanobacteria. The molecular mechanism of this clock has been efficiently dissected using a luciferase reporter gene that reports the status of the clock.
T, Kondo, M, Ishiura
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Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock
Cell Metabolism, 2018 Summary Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the idea that a molecular clock is necessary for metabolic homeostasis. However, these mice often lack a normal feeding-fasting cycle. We tested whether time-
A. Chaix +4 more
semanticscholar +1 more source
The Circadian Clock in the Kidney [PDF]
Journal of the American Society of Nephrology, 2011 Circadian variations in renal function were first described in the 19th century, and GFR, renal blood flow, urine production, and electrolyte excretion exhibit daily oscillations. These clinical observations are well established, but the underlying mechanisms that govern circadian fluctuations in kidney are not fully understood. Here we provide a brief
Lisa R, Stow, Michelle L, Gumz
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The Circadian Clock and Viral Infections [PDF]
Journal of Biological Rhythms, 2020 The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections.
Helene Borrmann +2 more
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Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. [PDF]
PLoS ONE, 2014 U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate
Julia Hoffmann +5 more
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The circadian clock and asthma [PDF]
Thorax, 2013 It is characteristic of asthma that symptoms worsen overnight, particularly in the early hours of the morning. Nocturnal symptoms in asthma are common and are an important indicator for escalation of treatment. An extensive body of research has demonstrated that nocturnal symptoms of cough and dyspnea are accompanied by circadian variations in airway ...
Durrington, Hannah J.; id_orcid 0000-0002-9990-9446 +3 more
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Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.
PLoS Genetics, 2012 The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues.
Michael E Hughes +7 more
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NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.
PLoS Genetics, 2016 Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN), the master circadian pacemaker, CLOCK-deficient mice ...
Dominic Landgraf +3 more
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Biologia Plantarum, 2018 Strawberry is an economically important fruit crop worldwide. Circadian clock genes are endogenous timers that regulate a wide range of metabolic processes and consequently plant development.
X. D. Chen, J. Wang, M. Z. Zhao, F. Zhao
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PLoS Biology, 2020 A ubiquitous feature of the circadian clock across life forms is its organization as a network of cellular oscillators, with individual cellular oscillators within the network often exhibiting considerable heterogeneity in their intrinsic periods.
K L Nikhil, Sandra Korge, Achim Kramer
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