Results 51 to 60 of about 372,746 (304)
NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1
bioRxiv, 2020 In mammals, the circadian clock coordinates various cell physiological processes, including the inflammatory response. Recent studies suggested a crosstalk between these two pathways. However, the mechanism of how inflammation affects the circadian clock
Yang Shen +10 more
semanticscholar +1 more source
Neoplasia: An International Journal for Oncology Research, 2015 Clock circadian regulator (CLOCK)/brain and muscle arnt-like protein-1 (BMAL1) complex governs the regulation of circadian rhythm through triggering periodic alterations of gene expression.
Ming Cui +5 more
doaj +1 more source
The Circadian Clock and Viral Infections [PDF]
Journal of Biological Rhythms, 2020 The circadian clock controls several aspects of mammalian physiology and orchestrates the daily oscillations of biological processes and behavior. Our circadian rhythms are driven by an endogenous central clock in the brain that synchronizes with clocks in peripheral tissues, thereby regulating our immune system and the severity of infections.
Helene Borrmann +2 more
openaire +2 more sources
Non-circadian expression masking clock-driven weak transcription rhythms in U2OS cells. [PDF]
PLoS ONE, 2014 U2OS cells harbor a circadian clock but express only a few rhythmic genes in constant conditions. We identified 3040 binding sites of the circadian regulators BMAL1, CLOCK and CRY1 in the U2OS genome. Most binding sites even in promoters do not correlate
Julia Hoffmann +5 more
doaj +1 more source
Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock
Cell Metabolism, 2018 Summary Increased susceptibility of circadian clock mutant mice to metabolic diseases has led to the idea that a molecular clock is necessary for metabolic homeostasis. However, these mice often lack a normal feeding-fasting cycle. We tested whether time-
A. Chaix +4 more
semanticscholar +1 more source
Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.
PLoS Genetics, 2012 The circadian regulatory network is organized in a hierarchical fashion, with a central oscillator in the suprachiasmatic nuclei (SCN) orchestrating circadian oscillations in peripheral tissues.
Michael E Hughes +7 more
doaj +1 more source
NPAS2 Compensates for Loss of CLOCK in Peripheral Circadian Oscillators.
PLoS Genetics, 2016 Heterodimers of CLOCK and BMAL1 are the major transcriptional activators of the mammalian circadian clock. Because the paralog NPAS2 can substitute for CLOCK in the suprachiasmatic nucleus (SCN), the master circadian pacemaker, CLOCK-deficient mice ...
Dominic Landgraf +3 more
doaj +1 more source
Biologia Plantarum, 2018 Strawberry is an economically important fruit crop worldwide. Circadian clock genes are endogenous timers that regulate a wide range of metabolic processes and consequently plant development.
X. D. Chen, J. Wang, M. Z. Zhao, F. Zhao
doaj +1 more source
PLoS Biology, 2020 A ubiquitous feature of the circadian clock across life forms is its organization as a network of cellular oscillators, with individual cellular oscillators within the network often exhibiting considerable heterogeneity in their intrinsic periods.
K L Nikhil, Sandra Korge, Achim Kramer
doaj +1 more source
Circadian clock protein Rev-erbα regulates neuroinflammation
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Disruptions in the circadian clock and its component proteins have been shown to be associated with disease states ranging from cancer to neurodegeneration.
Percy Griffin +14 more
semanticscholar +1 more source