Results 61 to 70 of about 369,771 (309)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
A scenario of unhealthy life cycle: The role of circadian rhythms in health
Aging MedicineCircadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer.
Manasa Chandramouli +2 more
doaj +1 more source
In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress
Journal of Circadian Rhythms, 2016 Mammalian circadian rhythms are governed by an endogenous circadian clock system, including the molecular clock works in each cell and tissue. Adaptation of the circadian clock to different environmental stimuli such as light, food, and stress is ...
Yu Tahara +6 more
doaj +1 more source
Plants, 2023 The circadian clock, an endogenous timing system, exists in nearly all organisms on Earth. The plant circadian clock has been found to be intricately linked with various essential biological activities. Extensive studies of the plant circadian clock have
Xingwei Wang, Yanfei Hu, Wei Wang
doaj +1 more source
Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism
Journal of Molecular Endocrinology, 2018 The mammalian circadian clock has evolved as an adaptation to the 24-hour light/dark cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems ...
Kimberly H. Cox, J. Takahashi
semanticscholar +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Circadian clocks control various aspects of physiology. The circadian control of the response of T cells to antigen presentation, which is at the core of the specific immune response to pathogens, has remained unclear.
C. Nobis +5 more
semanticscholar +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
Role of Sleep Restriction in Daily Rhythms of Expression of Hypothalamic Core Clock Genes in Mice
Current Issues in Molecular Biology, 2022 Lack of sleep time is a menace to modern people, and it leads to chronic diseases and mental illnesses. Circadian processes control sleep, but little is known about how sleep affects the circadian system.
Weitian Li +4 more
doaj +1 more source
Scientific Reports, 2018 Microbiota-derived short-chain fatty acids (SCFAs) and organic acids produced by the fermentation of non-digestible fibre can communicate from the microbiome to host tissues and modulate homeostasis in mammals.
Yu Tahara +9 more
semanticscholar +1 more source