Results 61 to 70 of about 256,062 (252)

Conditional circadian regulation of PHYTOCHROME A gene expression [PDF]

, 2001
The phytochrome photoreceptors and the circadian clock control many of the same developmental processes, in all organs and throughout the growth of Arabidopsis plants. Phytochrome A (phyA) provides light input signals to entrain the circadian clock.
Nagy, F, Hall, Anthony, Kozma-Bognár, L, Tóth, R, Millar, A J; id_orcid   +4 more
core   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans

Communications Biology
Animals have internal clocks that generate biological rhythms. In mammals, clock genes such as Period form the circadian clock to generate approximately 24-h biological rhythms. In C. elegans, the clock gene homologs constitute the “developmental clock”,
Shingo Hiroki, Hikari Yoshitane
doaj   +1 more source

Role of circadian clock in oral squamous cell carcinoma pathogenesis and treatment

Cancer Treatment and Research Communications
The circadian clock is an endogenous timing mechanism that enables cellular physiological activities to adapt to environmental changes. It is primarily composed of circadian clock genes and their encoded proteins, which form a transcription–translation ...
Mingyuan Liu, Kai Yang
doaj   +1 more source

Emerging roles for microRNA in the regulation of Drosophila circadian clock

BMC Neuroscience, 2018
Background The circadian clock, which operates within an approximately 24-h period, is closely linked to the survival and fitness of almost all living organisms. The circadian clock is generated through a negative transcription-translation feedback loop.
Yongbo Xue, Yong Zhang
doaj   +1 more source

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. [PDF]

PLoS ONE, 2011
Circadian clocks coordinate the timing of important biological processes. Interconnected transcriptional and post-translational feedback loops based on a set of clock genes generate and maintain these rhythms with a period of about 24 hours.
Isabelle Schmutz, Sabrina Wendt, Anna Schnell, Achim Kramer, Isabelle M Mansuy, Urs Albrecht   +5 more
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

The TIME FOR COFFEE gene maintains the amplitude and timing of Arabidopsis circadian clocks [PDF]

, 2003
Plants synchronize developmental and metabolic processes with the earth's 24-h rotation through the integration of circadian rhythms and responses to light.
Amasino, R., Hanano, S., Sung, S., Millar, A., Davis, S. J., McWatters, Harriet G, Sung, S, Doyle, M., Bastow, R. M., Hibberd, V, Doyle, MR, Millar, A. J., Sung, Sibum, Bastow, Ruth M, Davis, SJ, Bastow, R., McWatters, H., Davis, Seth J, Hanano, Shigeru, Hibberd, Victoria, Millar, AJ, Amasino, RM, Halliday, K., Doyle, M. R., Davis, S., Hibberd, V., Sung, S. B., Halliday, Karen J, Hall, Anthony, Amasino, Richard M, Doyle, Mark R, Amasino, R. M., Halliday, K. J., Bastow, RM, McWatters, H. G., Hanano, S, Millar, Andrew J; id_orcid, Halliday, KJ, Hall, A., Mcwatters, Harriet, Hall, A   +40 more
core   +1 more source

HD‐tDCS Restores Perivascular AQP4 Polarization via PPARγ Modulation to Enhance Glymphatic Clearance After Intracerebral Hemorrhage in Mice

Advanced Science, EarlyView.
HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li, Yingmei Zhang, Qianqian Tong, Zhitao Gong, Shanyu Zhang, Zhen Qian, Hui Zhang, Qian Yao, Qi Li   +8 more
wiley   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source