Results 61 to 70 of about 301,259 (301)

Experimental validation of a predicted feedback loop in the multi-oscillator clock of Arabidopsis thaliana [PDF]

, 2006
Our computational model of the circadian clock comprised the feedback loop between LATE ELONGATED HYPOCOTYL (LHY), CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and TIMING OF CAB EXPRESSION 1 (TOC1), and a predicted, interlocking feedback loop involving TOC1 and a
Nagy, Ferenc, Turner, Matthew S., Andrew J Millar, Gould, Peter D, Anthony Hall, Locke, James C. W., Kozma-Bognar, Laszlo, Balázs Fehér, Ferenc Nagy, Hall, Anthony, Matthew S Turner, Kevei, Eva, László Kozma‐Bognár, Gould, Peter D., Turner, Matthew S, James C W Locke, Peter D Gould, Millar, Andrew J; id_orcid, Millar, A. J. (Andrew J.), Éva Kevei, Locke, James C W, Feher, Balazs   +21 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Circadian Clocks, Stress, and Immunity [PDF]

Frontiers in Endocrinology, 2016
In mammals, molecular circadian clocks are present in most cells of the body, and this circadian network plays an important role in synchronizing physiological processes and behaviors to the appropriate time of day. The hypothalamic-pituitary-adrenal endocrine axis regulates the response to acute and chronic stress, acting through its final effectors -
Dumbell, R, Matveeva, O, Oster, H
openaire   +3 more sources

Global parameter search reveals design principles of the mammalian circadian clock [PDF]

, 2008
Background: Virtually all living organisms have evolved a circadian (~24 hour) clock that controls physiological and behavioural processes with exquisite precision throughout the day/night cycle.
Locke, James C. W., Kramer, Achim, Herzel, Hanspeter, Westermark, Pål O.   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A scenario of unhealthy life cycle: The role of circadian rhythms in health

Aging Medicine
Circadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer.
Manasa Chandramouli, Vrushabendra Basavanna, Srikantamurthy Ningaiah   +2 more
doaj   +1 more source

Characterization and expression analysis of circadian clock genes in the diploid woodland strawberry Fragaria vesca

Biologia Plantarum, 2018
Strawberry is an economically important fruit crop worldwide. Circadian clock genes are endogenous timers that regulate a wide range of metabolic processes and consequently plant development.
X. D. Chen, J. Wang, M. Z. Zhao, F. Zhao
doaj   +1 more source

SnapShot: Circadian Clock

Cell, 2017
Most creatures on this planet possess an ability to anticipate upcoming events in the environment, courtesy of their circadian clocks. This allows them to prepare for those changes instead of being caught by surprise, which could mean the difference between life and death. In this SnapShot, we describe the basics of how the clock ticks.
Bryan J, Song, Dragana, Rogulja
openaire   +2 more sources

Balance equations can buffer noisy and sustained environmental perturbations of circadian clocks [PDF]

, 2010
We present a new approach to understanding how regulatory networks such as circadian clocks might evolve robustness to environmental fluctuations. The approach is in terms of new balance equations that we derive.
David A. Rand, Domijan, Mirela, Rand, D. A. (David A.), Mirela Domijan   +3 more
core   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source