Results 81 to 90 of about 372,746 (304)

A scenario of unhealthy life cycle: The role of circadian rhythms in health

Aging Medicine
Circadian rhythms are oscillations in physiology and behavior caused by the circadian regulator. Cryptochromes, Periods, and Bmal1 are circadian clock genes that have been linked to aging and cancer.
Manasa Chandramouli, Vrushabendra Basavanna, Srikantamurthy Ningaiah   +2 more
doaj   +1 more source

In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress

Journal of Circadian Rhythms, 2016
Mammalian circadian rhythms are governed by an endogenous circadian clock system, including the molecular clock works in each cell and tissue. Adaptation of the circadian clock to different environmental stimuli such as light, food, and stress is ...
Yu Tahara, Ayako Yokota, Takuya Shiraishi, Shunya Yamada, Atsushi Haraguchi, Ayako Shinozaki, Shigenobu Shibata   +6 more
doaj   +1 more source

Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. [PDF]

PLoS ONE, 2010
Cell proliferation in all rapidly renewing mammalian tissues follows a circadian rhythm that is often disrupted in advanced-stage tumors. Epidemiologic studies have revealed a clear link between disruption of circadian rhythms and cancer development in ...
Susie Lee, Lawrence A Donehower, Alan J Herron, David D Moore, Loning Fu   +4 more
doaj   +1 more source

Hypoxia induces a time- and tissue-specific response that elicits intertissue circadian clock misalignment

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Circadian clocks are present in most cells of the body and act in concert to coordinate our daily physiology and behavior with the environment.
Gal Manella, Rona Aviram, N. Bolshette, Sapir Muvkadi, Marina Golik, David F. Smith, Gad Asher   +6 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

SnapShot: Circadian Clock

Cell, 2017
Most creatures on this planet possess an ability to anticipate upcoming events in the environment, courtesy of their circadian clocks. This allows them to prepare for those changes instead of being caught by surprise, which could mean the difference between life and death. In this SnapShot, we describe the basics of how the clock ticks.
Bryan J, Song, Dragana, Rogulja
openaire   +2 more sources

Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism

Journal of Molecular Endocrinology, 2018
The mammalian circadian clock has evolved as an adaptation to the 24-hour light/dark cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism (such as eating and sleeping) helps different tissue and organ systems ...
Kimberly H. Cox, J. Takahashi
semanticscholar   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Circadian clocks control various aspects of physiology. The circadian control of the response of T cells to antigen presentation, which is at the core of the specific immune response to pathogens, has remained unclear.
C. Nobis, Geneviève Dubeau Laramée, L. Kervezee, Dave Maurice De Sousa, N. Labrecque, N. Cermakian   +5 more
semanticscholar   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source