Results 101 to 110 of about 372,746 (304)
Advanced Science, EarlyView.This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang +16 more
wiley +1 more source
Ror homolog nhr-23 is essential for both developmental clock and circadian clock in C. elegans
Communications BiologyAnimals have internal clocks that generate biological rhythms. In mammals, clock genes such as Period form the circadian clock to generate approximately 24-h biological rhythms. In C. elegans, the clock gene homologs constitute the “developmental clock”,
Shingo Hiroki, Hikari Yoshitane
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Auto‐Downregulation of the Florigen FT Production Prevents Precocious Flowering in Plants
Advanced Science, EarlyView.This study shows that the leaf vein‐expressed FD complexes with the florigen FT to bind DNA motifs in FT promoter, which antagonizes CONSTANS‐mediated FT activation to feedback down‐regulate FT expression. This prevents an excessive induction of FT expression by inductive photoperiods, thereby precluding precocious transition to flowering in ...
Shu Tian, Xiao Luo, Bowen Cui, Yuehui He
wiley +1 more source
Glucocorticoids and the circadian clock [PDF]
Journal of Endocrinology, 2008 Glucocorticoids, hormones produced by the adrenal gland cortex, perform numerous functions in body homeostasis and the response of the organism to external stressors. One striking feature of their regulation is a diurnal release pattern, with peak levels linked to the start of the activity phase. This release is under control of the circadian clock, an
openaire +3 more sources
The circadian clock coordinates ribosome biogenesis.
PLoS Biology, 2013 Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of ...
Céline Jouffe +6 more
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Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. [PDF]
PLoS ONE, 2012 Accumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a direct cause of metabolic dysregulation such as body weight gain is not clearly understood. In this
Hagoon Jang +5 more
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Neurobiology of Sleep and Circadian Rhythms, 2018 Sleep is regulated by a homeostatic and a circadian process. Together these two processes determine most aspects of sleep and related variables like sleepiness and alertness.
T. Deboer
semanticscholar +1 more source
Synchronization‐Dissipation in the Cardiorespiratory System
Advanced Science, EarlyView.By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border +3 more
wiley +1 more source
The Molecular Circadian Clock and Alcohol-Induced Liver Injury
Biomolecules, 2015 Emerging evidence from both experimental animal studies and clinical human investigations demonstrates strong connections among circadian processes, alcohol use, and alcohol-induced tissue injury.
Uduak S. Udoh +3 more
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Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. [PDF]
PLoS ONE, 2011 Circadian clocks coordinate the timing of important biological processes. Interconnected transcriptional and post-translational feedback loops based on a set of clock genes generate and maintain these rhythms with a period of about 24 hours.
Isabelle Schmutz +5 more
doaj +1 more source