Results 101 to 110 of about 301,259 (301)

Circadian‐Inspired Hydrogel Moisture Electricity Generation

Advanced Science, EarlyView.
A circadian‐inspired hydrogel moisture‐electric generator enables sustainable electricity generation by autonomously current direction switching between daytime and nighttime. This reversible output is accompanied by inversion of the internal water gradient, which effectively reduce hydrogel fatigue and offers a new strategy for harvesting diurnal ...
Ziqi Li, Dilalanmu Ahemaitijiang, Hongfei Yang, Xuan Zhao, Mengjiao Pan, Jun Wan, Pingan Zhu, Dahua Shou   +7 more
wiley   +1 more source

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

The Molecular Circadian Clock and Alcohol-Induced Liver Injury

Biomolecules, 2015
Emerging evidence from both experimental animal studies and clinical human investigations demonstrates strong connections among circadian processes, alcohol use, and alcohol-induced tissue injury.
Uduak S. Udoh, Jennifer A. Valcin, Karen L. Gamble, Shannon M. Bailey   +3 more
doaj   +1 more source

Extension of a genetic network model by iterative experimentation and mathematical analysis [PDF]

, 2005
Circadian clocks involve feedback loops that generate rhythmic expression of key genes. Molecular genetic studies in the higher plant Arabidopsis thaliana have revealed a complex clock network.
Turner, Matthew S., Victoria Hibberd, Andrew J Millar, Paul E Brown, Hibberd, Victoria, Locke, James C. W., Kozma-Bognar, Laszlo, Hibberd, V. (Victoria), Southern, Megan M, Matthew S Turner, László Kozma‐Bognár, Southern, Megan M., Brown, Paul E, Turner, Matthew S, James C W Locke, James Cw Locke, Millar, Andrew J; id_orcid, Brown, Paul E., Millar, A. J. (Andrew J.), Megan M Southern, Locke, James C W   +20 more
core   +1 more source

Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High‐Fat Diet‐Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Polystyrene nanoplastics exacerbate high‐fat diet‐induced metabolic dysfunction in an age‐dependent manner. Juvenile mice exhibit greater susceptibility, characterized by circadian disruption, impaired mitochondrial function, reduced energy metabolism, and enhanced hepatic lipid accumulation.
Peihao Xu, Shuting Huang, Leilei Zhu, Junyi Huang, Kewei Li, Guangming Li, Jiannong Wu, Mingyuan Zhou, Fangmei Zhou, Zhishan Ding, Yingzhi Shen   +10 more
wiley   +1 more source

The circadian architecture of tumor immunity: mechanistic insights and treatment strategies

Biomarker Research
Background The circadian clock orchestrates many key physiological processes related to anti-tumor immunity, including the cell cycle, energy metabolism, immune infiltration, and cytokine secretion.
Hao Wang, Bin Guo, Danfeng Li, Yuxi Liu, Kun Cheng, Wanguang Zhang, Huifang Liang   +6 more
doaj   +1 more source

Physcion Protects Against Ethanol-Induced Liver Injury by Reprogramming of Circadian Clock

Frontiers in Pharmacology, 2020
The circadian clock plays a key role in our daily physiology and metabolism. Alcohol consumption disrupts the circadian rhythm of metabolic genes in the liver; however, the potential contribution of circadian clock modulation to alcoholic liver disease ...
Youli Yao, Along Zuo, Qiyu Deng, Shikang Liu, Tianying Zhan, Maolin Wang, Haidong Xu, Junxian Ma, Yingying Zhao   +8 more
doaj   +1 more source

Structural investigation of the Arabidopsis thaliana circadian clock [PDF]

Plants, like most organisms, have developed elaborate mechanisms for anticipating periodic environmental changes. The circadian clock allows an organism to adapt its metabolic, developmental and physiological processes to coincide with favourable ...
Durrant, Oliver
core  

Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE [PDF]

, 2006
The circadian system of Arabidopsis ( Arabidopsis thaliana) includes feedback loops of gene regulation that generate 24-h oscillations. Components of these loops remain to be identified; none of the known components is completely understood, including ...
Gyula, Peter, Hanano, S., Southern, M., Millar, A., Eriksson, Maria,, Kevei, Eva, Davis, Seth J., Millar, A. J., Somers, D., Bastow, Ruth M, Somers, David E, Bastow, R., Viczian, A., Kozma-Bognar, L., Eriksson, Maria E., Viczian, Andras, Nagy, Ferenc, Davis, Seth J, Hanano, Shigeru, Hibberd, Victoria, Kevei, E., Davis, S., Kozma-Bognar, Laszlo, Millar, Andrew J, Bastow, Ruth, Hibberd, V., Toth, R., Kim, Woe-Yeon, Southern, Megan M, Hall, Anthony, Eriksson, Maria E, Kim, W., Somers, David E., Eriksson, M., Southern, Megan M., Gyula, P., Toth, Reka, Millar, Andrew J; id_orcid, Hall, A., Nagy, F., Feher, Balazs, Feher, B.   +41 more
core   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source