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Circadian clocks: It's time for chronobiology.
PLoS Biology, 2023 Circadian clocks are everywhere, yet we still have not translated the vast knowledge gained in the past 20 years on the properties of circadian clocks into practical applications.
Martha Merrow
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Adaptive Significance of Circadian Clocks
Chronobiology International, 2003 Circadian clocks are ubiquitous and are found in organisms ranging from bacteria to mammals. This ubiquity of occurrence implies adaptive significance, but to date there has been no rigorous empirical evidence to support this.
Sharma, Vijay Kumar
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Hundreds of LncRNAs Display Circadian Rhythmicity in Zebrafish Larvae
Cells, 2021 Long noncoding RNAs (lncRNAs) have been shown to play crucial roles in various life processes, including circadian rhythms. Although next generation sequencing technologies have facilitated faster profiling of lncRNAs, the resulting datasets require ...
Shital Kumar Mishra +2 more
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Computational Analysis Predicts Hundreds of Coding lncRNAs in Zebrafish
Biology, 2021 Recent studies have demonstrated that numerous long noncoding RNAs (ncRNAs having more than 200 nucleotide base pairs (lncRNAs)) actually encode functional micropeptides, which likely represents the next regulatory biology frontier.
Shital Kumar Mishra, Han Wang
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Real time, in vivo measurement of neuronal and peripheral clocks in Drosophila melanogaster
eLife, 2022 Circadian clocks are highly conserved transcriptional regulators that control ~24 hr oscillations in gene expression, physiological function, and behavior.
Peter S Johnstone +6 more
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A broken circadian clock: The emerging neuro-immune link connecting depression to cancer
Brain, Behavior, & Immunity - Health, 2022 Circadian clocks orchestrate daily rhythms in many organisms and are essential for optimal health. Circadian rhythm disrupting events, such as jet-lag, shift-work, night-light exposure and clock gene alterations, give rise to pathologic conditions that ...
Keyu Su +11 more
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New Insights Into Cancer Chronotherapies
Frontiers in Pharmacology, 2021 Circadian clocks participate in the coordination of various metabolic and biological activities to maintain homeostasis. Disturbances in the circadian rhythm and cancers are closely related.
Jingxuan Zhou +10 more
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Organoids as Model Systems to Investigate Circadian Clock-Related Diseases and Treatments
Frontiers in Genetics, 2022 Circadian rhythms exist in most cell types in mammals regulating temporal organization of numerous cellular and physiological processes ranging from cell cycle to metabolism.
Suengwon Lee, Christian I. Hong
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Balance equations can buffer noisy and sustained environmental perturbations of circadian clocks [PDF]
, 2010 We present a new approach to understanding how regulatory networks such as circadian clocks might evolve robustness to environmental fluctuations. The approach is in terms of new balance equations that we derive.
David A. Rand +3 more
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Cell Reports, 2020 Summary: Circadian clocks are endogenous oscillators that generate cell-autonomous rhythms that govern cellular processes and are synchronized by external cues in the local macro- and micro-environments.
Suihong Huang +5 more
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