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Organoids as Model Systems to Investigate Circadian Clock-Related Diseases and Treatments
Circadian rhythms exist in most cell types in mammals regulating temporal organization of numerous cellular and physiological processes ranging from cell cycle to metabolism.
Suengwon Lee, Christian I. Hong
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Rhythmicity is a fundamental characteristic of every living organism [...]
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Summary: Circadian clocks are endogenous oscillators that generate cell-autonomous rhythms that govern cellular processes and are synchronized by external cues in the local macro- and micro-environments.
Suihong Huang +5 more
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Most creatures on this planet possess an ability to anticipate upcoming events in the environment, courtesy of their circadian clocks. This allows them to prepare for those changes instead of being caught by surprise, which could mean the difference between life and death. In this SnapShot, we describe the basics of how the clock ticks.
Bryan J, Song, Dragana, Rogulja
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Spectres of Clock Evolution: Past, Present, and Yet to Come
Circadian clocks are phylogenetically widespread biological oscillators that allow organisms to entrain to environmental cycles and use their steady-state phase relationship to anticipate predictable daily phenomena – such as the light-dark transitions ...
Maria Luísa Jabbur +1 more
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Circadian Clocks and Pregnancy [PDF]
The recognition that 24-h rhythmic processes (“circadian”) underlie many endocrine functions has added a fascinating new temporal dimension to our appreciation of their complexity. Research from various laboratories has revealed circadian gene expression in multiple tissues in the reproductive system of non-pregnant and pregnant mammals.
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Disrupted circadian clocks and altered tissue mechanics in primary human breast tumours
Background Circadian rhythms maintain tissue homeostasis during the 24-h day-night cycle. Cell-autonomous circadian clocks play fundamental roles in cell division, DNA damage responses and metabolism.
Eleanor Broadberry +10 more
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Importance of circadian timing for aging and longevity
Circadian clocks link physiologic processes to environmental conditions and a mismatch between internal and external rhythms has negative effects on organismal health.
Victoria A. Acosta-Rodríguez +3 more
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The circadian control of eating
Eating is a complex behavior that is primarily governed by energy homeostasis and modulated by hedonic cues. Eating is also structured in time, due to circadian clocks that control its daily rhythmicity.
Etienne Challet
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Heterogeneity of the Peripheral Circadian Systems in Drosophila melanogaster: A Review
Circadian rhythms in organisms are involved in many aspects of metabolism, physiology, and behavior. In many animals, these rhythms are produced by the circadian system consisting of a central clock located in the brain and peripheral clocks in various ...
Chihiro eIto, Kenji eTomioka
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