Results 91 to 100 of about 256,062 (252)

Mesoporous PU/PEDOT:PSS Electrodes Reveal Population‐Level Stochastic Bioelectrical Dynamics in Marine Diatoms

Advanced Science, EarlyView.
Mesoporous mixed ionic‐electronic PU/PEDOT: PSS electrodes enable label‐free detection of stochastic extracellular bioelectrical dynamics in living Phaeodactylum tricornutum. Living diatoms actively modulate interfacial ionic dynamics, establishing stochastic electrochemical noise as a sensitive probe of microbial bioelectrochemical activity and a new ...
David M. S. Silva, Felipe L. Bacellar, Raquel Amaral, Louis‐Josselin Lavier‐Aydat, Luísa Cortes, Kamal Asadi, Leïla Tirichine, Paulo R. F. Rocha   +7 more
wiley   +1 more source

Non-alcoholic Fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms. [PDF]

, 2014
Emerging evidence suggests that maternal obesity (MO) predisposes offspring to obesity and the recently described non-alcoholic fatty pancreas disease (NAFPD) but involved mechanisms remain unclear.
Mouralidarane Angelina, Chiara Saracino, Lucilla Poston (200809), Francesca Rappa, Ruma Saraswati, Fusai, Giuseppe, Paul D. Taylor (200813), Pazienza Valerio, Junpei Soeda, Carter, Rebeca, Jude A Oben, Angelina Mouralidarane (540950), Saraswati Ruma, Paul D Taylor, Mouralidarane, Angelina, Oben, JA, Saraswati, R, Fusai Giuseppe, Marco Novelli, Carter, R, Poston Lucilla, Marco Novelli (540954), Giuseppe Fusai (540955), Shuvra Ray (540951), Soeda, Junpei, Soeda, J, Pombo, J, Mouralidarane, A, Rappa, F, Ruma Saraswati (540953), Pazienza, Valerio, Novelli, Marco, Taylor Paul D., Joaquim Pombo (540952), Carter Rebeca, Saracino, C, Manlio Vinciguerra (287299), Saraswati, Ruma, Novelli, M, Oben, Jude A, Angelina Mouralidarane, Pombo, Joaquim, Fusai, G, RAPPA, Francesca, Saracino, Chiara, Novelli Marco, Rappa Francesca, Lucilla Poston, Francesca Rappa (55683), Manlio Vinciguerra, Rebeca Carter, Saracino Chiara, Poston, Lucilla; id_orcid, Pazienza, V, Vinciguerra, M, Joaquim Pombo, Rebeca Carter (540949), Ray Shuvra, Vinciguerra, Manlio, Vinciguerra, M. Oben J.A., Junpei Soeda (453348), Valerio Pazienza, Poston, L, Vinciguerra Manlio, Ray, S, Jude A. Oben (453352), Taylor, PD, Soeda Junpei, Giuseppe Fusai, Oben Jude A., Pombo Joaquim, Valerio Pazienza (174196), Taylor, Paul D; id_orcid, Chiara Saracino (540956), Ray, Shuvra, Shuvra Ray   +75 more
core   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Circadian clock control of Nox4 and reactive oxygen species in the vasculature.

PLoS ONE, 2013
Recent studies have shown that circadian clock disruption is associated with pathological remodeling in the arterial structure and vascular stiffness.
Ciprian B Anea, Maoxiang Zhang, Feng Chen, M Irfan Ali, C Michael M Hart, David W Stepp, Yevgeniy O Kovalenkov, Ana-Maria Merloiu, Paramita Pati, David Fulton, R Daniel Rudic   +10 more
doaj   +1 more source

Statistical inference of regulatory networks for circadian regulation [PDF]

, 2014
The work described in the present article is part of the TiMet project on linking the circadian clock to metabolism in plants. TiMet is a collaborative project (Grant Agreement 245143) funded by the European Commission FP7, in response to call FP7-KBBE ...
Aderhold, Andrej, Husmeier, Dirk, Grzegorczyk, Marco   +2 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Diurnal rhythms in neurexins transcripts and inhibitory/excitatory synapse scaffold proteins in the biological clock [PDF]

, 2012
The neurexin genes (NRXN1/2/3) encode two families (α and β) of highly polymorphic presynaptic proteins that are involved in excitatory/inhibitory synaptic balance.
Hendricks, Michael, Shapiro-Reznik, Mika, Hadas Lerner, Anje Jilg, Jilg Anje, Earnest, David J., Earnest David J., Nava Zisapel, Zisapel, Nava, Lerner Hadas, Jilg, Anje, Mika Shapiro-Reznik, Zisapel Nava, Lerner, Hadas, David J Earnest, Shapiro-Reznik Mika   +15 more
core   +2 more sources

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures [PDF]

, 2014
Sleep and circadian rhythms are intrinsically linked, with several sleep traits, including sleep timing and duration, influenced by both sleep homeostasis and the circadian phase.
Lester, Kathryn, Lester, KJ, Archer, Simon, Archer, SN, Gregory, Alice M, Lester, Kathryn J., Barclay, Nicola L., Gregory, Alice, Nolan, Patrick M., Nolan, PM, Nolan, Patrick, Parsons, Michael J., Eley, Thalia C, Archer, Simon N., Barclay, Nicola, Gregory, AM, Patrick M Nolan (11641339), Barclay, Nicola L, Eley, Thalia C., Nolan, Patrick M, Archer, Simon N, Parsons, Michael J, Kathryn Lester (4462210), Nicola L Barclay (16221641), Parsons, Michael, Thalia C Eley (13615696), Parsons, MJ, Eley, Thalia, Simon N Archer (16221644), Alice M Gregory (11992776), Lester, Kathryn J, Michael J Parsons (16221638), Gregory, Alice M., Eley, TC, Barclay, NL   +34 more
core   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source