Results 71 to 80 of about 369,771 (309)
Circadian rhythms in the absence of the clock gene Bmal1
Science, 2020 Redundancy in circadian clocks? The transcription factor BMAL1 is a core component of the mammalian circadian clock; without it, circadian behaviors are abolished. However, Ray et al.
Sandipan Ray +6 more
semanticscholar +1 more source
ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Evidence for widespread dysregulation of circadian clock progression in human cancer [PDF]
PeerJ, 2018 The ubiquitous daily rhythms in mammalian physiology are guided by progression of the circadian clock. In mice, systemic disruption of the clock can promote tumor growth. In vitro, multiple oncogenes can disrupt the clock.
Jarrod Shilts +2 more
doaj +2 more sources
Period 2: A Regulator of Multiple Tissue-Specific Circadian Functions
Frontiers in Molecular Neuroscience, 2021 The zebrafish represents a powerful model for exploring how light regulates the circadian clock due to the direct light sensitivity of its peripheral clocks, a property that is retained even in organ cultures as well as zebrafish-derived cell lines ...
Gennaro Ruggiero +8 more
doaj +1 more source
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
Science, 2017 Light, fat, and commensals The gut microbiota facilitates energy harvest from food and transfers it into fat storage. Working in mice, Wang et al.
Yuhao Wang +5 more
semanticscholar +1 more source
Associations of Sleep and Shift Work With Osteoarthritis Risk
Arthritis Care &Research, EarlyView.Objective Daily rhythms may be critical for maintaining homeostasis of joint tissues. We aimed to investigate the relationships among circadian clock disruption, sleep, and osteoarthritis (OA) risk in humans. Methods In the UK Biobank, a prospective 500,000–person cohort, we evaluated associations among sleep duration, sleeplessness/insomnia, and shift
Elizabeth L. Yanik +5 more
wiley +1 more source
Neuroimmunology of the circadian clock
Brain Research, 2008 Circadian timekeeping is a ubiquitous feature of all eukaryotes which allows for the imposition of a biologically appropriate temporal architecture on an animal's physiology, behavior and metabolism. There is growing evidence that in mammals the processes of circadian timing are under the influence of the immune system.
Coogan, Andrew, Wyse, Cathy A.
openaire +3 more sources
Photoperiodic plasticity in circadian clock neurons in insects
Frontiers in Physiology, 2013 Since Bünning’s observation of circadian rhythms and photoperiodism in the runner bean Phaseolus multiflorus in 1936, many studies have shown that photoperiodism is based on the circadian clock system.
Sakiko eShiga
doaj +1 more source
Feeding period restriction alters the expression of peripheral circadian rhythm genes without changing body weight in mice. [PDF]
PLoS ONE, 2012 Accumulating evidence suggests that the circadian clock is closely associated with metabolic regulation. However, whether an impaired circadian clock is a direct cause of metabolic dysregulation such as body weight gain is not clearly understood. In this
Hagoon Jang +5 more
doaj +1 more source
TIPS - Trends in Pharmacological Sciences, 2018 Daily rhythms in behavior, physiology, and metabolism are an integral part of homeostasis. These rhythms emerge from interactions among endogenous circadian clocks, ambient light-dark-, sleep-activity-, and eating-fasting cycles.
G. Sulli +3 more
semanticscholar +1 more source