Results 71 to 80 of about 301,259 (301)

Role of circadian clock in oral squamous cell carcinoma pathogenesis and treatment

Cancer Treatment and Research Communications
The circadian clock is an endogenous timing mechanism that enables cellular physiological activities to adapt to environmental changes. It is primarily composed of circadian clock genes and their encoded proteins, which form a transcription–translation ...
Mingyuan Liu, Kai Yang
doaj   +1 more source

Emerging roles for microRNA in the regulation of Drosophila circadian clock

BMC Neuroscience, 2018
Background The circadian clock, which operates within an approximately 24-h period, is closely linked to the survival and fitness of almost all living organisms. The circadian clock is generated through a negative transcription-translation feedback loop.
Yongbo Xue, Yong Zhang
doaj   +1 more source

Conditional circadian regulation of PHYTOCHROME A gene expression [PDF]

, 2001
The phytochrome photoreceptors and the circadian clock control many of the same developmental processes, in all organs and throughout the growth of Arabidopsis plants. Phytochrome A (phyA) provides light input signals to entrain the circadian clock.
Nagy, F, Hall, Anthony, Kozma-Bognár, L, Tóth, R, Millar, A J; id_orcid   +4 more
core   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli, Karine Lacourse, Hélène Blais, Anne‐Sophie Deshaies‐Rugama, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Christophe Moderie, Boshra Khajehpiri, Catherine Duclos, Jean Marc Lina, Julie Carrier, Nadia Gosselin   +13 more
wiley   +1 more source

The cyanobacterial circadian clock

npj Biological Timing and Sleep
This review summarizes recent advances in understanding the cyanobacterial circadian clock, emphasizing how the KaiA, KaiB, and KaiC proteins generate robust, temperature-compensated rhythms through ordered phosphorylation, conformational switching, and dynamic protein interactions. A comparative analysis of 30 KaiC structures under different states of
Chang, Yong-Gang, LiWang, Andy
openaire   +2 more sources

Non-alcoholic Fatty pancreas disease pathogenesis: a role for developmental programming and altered circadian rhythms. [PDF]

, 2014
Emerging evidence suggests that maternal obesity (MO) predisposes offspring to obesity and the recently described non-alcoholic fatty pancreas disease (NAFPD) but involved mechanisms remain unclear.
Mouralidarane Angelina, Chiara Saracino, Lucilla Poston (200809), Francesca Rappa, Ruma Saraswati, Fusai, Giuseppe, Paul D. Taylor (200813), Pazienza Valerio, Junpei Soeda, Carter, Rebeca, Jude A Oben, Angelina Mouralidarane (540950), Saraswati Ruma, Paul D Taylor, Mouralidarane, Angelina, Oben, JA, Saraswati, R, Fusai Giuseppe, Marco Novelli, Carter, R, Poston Lucilla, Marco Novelli (540954), Giuseppe Fusai (540955), Shuvra Ray (540951), Soeda, Junpei, Soeda, J, Pombo, J, Mouralidarane, A, Rappa, F, Ruma Saraswati (540953), Pazienza, Valerio, Novelli, Marco, Taylor Paul D., Joaquim Pombo (540952), Carter Rebeca, Saracino, C, Manlio Vinciguerra (287299), Saraswati, Ruma, Novelli, M, Oben, Jude A, Angelina Mouralidarane, Pombo, Joaquim, Fusai, G, RAPPA, Francesca, Saracino, Chiara, Novelli Marco, Rappa Francesca, Lucilla Poston, Francesca Rappa (55683), Manlio Vinciguerra, Rebeca Carter, Saracino Chiara, Poston, Lucilla; id_orcid, Pazienza, V, Vinciguerra, M, Joaquim Pombo, Rebeca Carter (540949), Ray Shuvra, Vinciguerra, Manlio, Vinciguerra, M. Oben J.A., Junpei Soeda (453348), Valerio Pazienza, Poston, L, Vinciguerra Manlio, Ray, S, Jude A. Oben (453352), Taylor, PD, Soeda Junpei, Giuseppe Fusai, Oben Jude A., Pombo Joaquim, Valerio Pazienza (174196), Taylor, Paul D; id_orcid, Chiara Saracino (540956), Ray, Shuvra, Shuvra Ray   +75 more
core   +1 more source

Disentangling the Genetic Relationship Between Sleep and Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective A bidirectional relationship between sleep and epilepsy is well recognised, yet the biological mechanisms linking them remain poorly understood. Both have a genetic basis, with genome‐wide association studies (GWAS) capturing polygenic contributions.
Khang N. Le, Victoria E. Jackson, Rachel E. Stirling, Zachary F. Gerring, Remi Stevelink, Samuel F. Berkovic, Ingrid E. Scheffer, Philippa J. Karoly, Melanie Bahlo, Karen L. Oliver   +9 more
wiley   +1 more source

Dynamic Physicochemical Gradients for Tendon–Bone Regeneration

Advanced Functional Materials, EarlyView.
Dynamic physicochemical gradients offer a framework for reconnecting soft tendon and hard bone. This Review examines how hydration, transport, loading and degradation reshape these gradients during healing. Coordinating regional biological cues with progressive transfer of load from scaffold to tissue guides the design of interfaces that retain ...
Wanxue Wang, Minsheng Zhu, Junmiao Liu, Haowen Lu, Haoteng Wang, Yu Chen, Hua Liu, Zhengyu Xu, Zhiyong Sun, Huilin Yang, Yusen Qiao, Xia Zhao   +11 more
wiley   +1 more source

In vitro and in vivo Phase Changes of the Mouse Circadian Clock by Oxidative Stress

Journal of Circadian Rhythms, 2016
Mammalian circadian rhythms are governed by an endogenous circadian clock system, including the molecular clock works in each cell and tissue. Adaptation of the circadian clock to different environmental stimuli such as light, food, and stress is ...
Yu Tahara, Ayako Yokota, Takuya Shiraishi, Shunya Yamada, Atsushi Haraguchi, Ayako Shinozaki, Shigenobu Shibata   +6 more
doaj   +1 more source

Life‐Like Ferrous Oxide Microspheres from Kombucha

Advanced Materials Interfaces, EarlyView.
Kombucha bacterial cellulose, sodium alginate, and ferrous nitrate self‐assemble into membrane‐enclosed iron oxide microspheres. These microspheres bud daughter vesicles, sustain 24‐h electrochemical oscillations, and filter theta‐band signals.
Panagiotis Mougkogiannis, Anna Nikolaidou, Andrew Adamatzky   +2 more
wiley   +1 more source