Results 121 to 130 of about 301,259 (301)

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Circadian synchronization between diet and gut microbiota in modulating host's health

Gut Microbes
Extensive research has established a complex relationship between the host, diet, and gut microbiota. Recent studies highlight the critical role of the host circadian clock in maintaining health.
Jianjun Ma, Yongkang Zhen, Yunan Weng, Jiaqi Lin, Chong Zhang, Yuhong Zhong, Jiaqi Zhou, Mengzhi Wang   +7 more
doaj   +1 more source

O-GlcNAcylation of PERIOD regulates its interaction with CLOCK and timing of circadian transcriptional repression.

PLoS Genetics, 2019
Circadian clocks coordinate time-of-day-specific metabolic and physiological processes to maximize organismal performance and fitness. In addition to light and temperature, which are regarded as strong zeitgebers for circadian clock entrainment ...
Ying H Li, Xianhui Liu, Jens T Vanselow, Haiyan Zheng, Andreas Schlosser, Joanna C Chiu   +5 more
doaj   +1 more source

The Input Signal Step Function (ISSF), a Standard Method to Encode Input Signals in SBML Models with Software Support, Applied to Circadian Clock Models [PDF]

, 2012
Time-dependent light input is an important feature of computational models of the circadian clock. However, publicly available models encoded in standard representations such as the Systems Biology Markup Language (SBML) either do not encode this input ...
Juty, N, Stratford, K, Gilmore, S; id_orcid, Le Novère, N, Tsorman, N, Akman, O E, Adams, R R, Millar, A J; id_orcid   +7 more
core   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Barley Hv CIRCADIAN CLOCK ASSOCIATED 1 and Hv PHOTOPERIOD H1 Are Circadian Regulators That Can Affect Circadian Rhythms in Arabidopsis.

PLoS ONE, 2015
Circadian clocks regulate many aspects of plant physiology and development that contribute to essential agronomic traits. Circadian clocks contain transcriptional feedback loops that are thought to generate circadian timing.
Jelena Kusakina, Zoe Rutterford, Sean Cotter, María C Martí, David A Laurie, Andy J Greenland, Anthony Hall, Alex A R Webb   +7 more
doaj   +1 more source

Blocking Honeybee Preference for Neonicotinoids by Interfering With Dopamine Signaling

Advanced Science, EarlyView.
Honeybees (Apis mellifera) paradoxically prefer nectar containing the harmful neonicotinoid thiamethoxam. This preference is associated with transient brain dopamine elevation during proboscis extension reflex (PER) responses and active feeding, and is reduced by the dopamine receptor antagonist fluphenazine.
Jing Li, Yuan Ge, Wangjiang Feng, David C. Lyon, Pingli Dai, Yong‐Jun Liu   +5 more
wiley   +1 more source

Prediction of photoperiodic regulators from quantitative gene circuit models [PDF]

, 2009
Photoperiod sensors allow physiological adaptation to the changing seasons. The external coincidence hypothesis postulates that a light-responsive regulator is modulated by a circadian rhythm.
James C.W. Locke, Carré, Isabelle A., Paul E. Brown, Julia Foreman, Saithong, Treenut, Halliday, Karen J., Isabelle A. Carré, Locke, James C. W., David A. Rand, Salazar, Jose Domingo, Rand, D. A. (David A.), Foreman, Julia, Andrew J. Millar, Karen J. Halliday, Treenut Saithong, Brown, Paul E., Millar, A. J. (Andrew J.), José Domingo Salazar   +17 more
core   +1 more source

A UBE3A‐UTX Proteostasis‐Epigenetic Axis Governs Hypothalamic Energy Homeostasis

Advanced Science, EarlyView.
Ubiquitin protein ligase E3A (UBE3A) regulates hypothalamic energy homeostasis and promotes degradation of the histone demethylase UTX (KDM6A). Neuronal UBE3A loss increases susceptibility to diet‐induced obesity and is accompanied by UTX accumulation, reduced histone H3 lysine 27 trimethylation, and altered endoplasmic reticulum stress‐responsive gene
Junekyoung Lee, Jaeyoung Yoo, Young A. Kim, Zhuodu Wei, Yunseo Lee, Woo‐Jeong Shon, Je Kyung Seong, Seunghee Lee   +7 more
wiley   +1 more source

A central role for ubiquitination within a circadian clock protein modification code

Frontiers in Molecular Neuroscience, 2014
Circadian rhythms, endogenous cycles of about 24 h in physiology, are generated by a master clock located in the suprachiasmatic nucleus of the hypothalamus and other clocks located in the brain and peripheral tissues.
Katarina eStojkovic, Simon S. Wing, Nicolas eCermakian   +2 more
doaj   +1 more source