Results 81 to 90 of about 619,220 (177)

A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells [PDF]

, 2016
Nuclear erythroid related factor-2 (NRF2) is known to promote cancer therapeutic detoxification and crosstalk with growth promoting pathways. HER2 receptor tyrosine kinase is frequently overexpressed in cancers leading to uncontrolled receptor activation
Bown, James, Deeni, Yusuf Y., Goltsov, Alexey, Harrison, David J., Khalil, Hilal S., Langdon, Simon P., Soininen, Tero   +6 more
core   +3 more sources

Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019
BACKGROUND White adipose tissue (WAT) have a relevant metabolic and inflammatory function, in overweight or obesity conditions. In this regard, the WAT under over feeding nutrition present a significant increment in oxidative stress, pro-inflammatory ...
P. Illesca, R. Valenzuela, A. Espinosa, F. Echeverría, S. Soto-Alarcón, M. Ortíz, L. Videla   +6 more
semanticscholar   +1 more source

Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. [PDF]

, 2015
Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions in these processes underlie many neurodevelopmental abnormalities.
Amaral, David G, Bakken, Trygve E, Bennett, Jeffrey L, Bernard, Amy, Bertagnolli, Darren, Geschwind, Daniel H, Lee, Chang-Kyu, Lein, Ed S, Luo, Rui, Miller, Jeremy A, Parikshak, Neelroop N, Smith, Kimberly A, Sunkin, Susan M   +12 more
core   +1 more source

ORIGINAL ARTICLE [PDF]

www.nature.com ...

core  

Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex [PDF]

, 2007

core   +1 more source

Bmal1 is required for beta cell compensatory expansion, survival and metabolic adaptation to diet-induced obesity in mice

Diabetologia, 2016
Kuntol Rakshit, Tu Wen Hsu, A. Matveyenko   +2 more
semanticscholar   +1 more source

RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice

Diabetologia, 2016
Xiang Ma, Zan Zhou, Yaqiong Chen, Yuting Wu, Yi Liu   +4 more
semanticscholar   +1 more source

Loss of coiled-coil domain containing 80 negatively modulates glucose homeostasis in diet-induced obese mice.

Endocrinology, 2012
Frédéric Tremblay, C. Huard, J. Dow, T. Gareski, S. Will, A. Richard, J. Syed, Steven A. Bailey, K. Brenneman, R. Martinez, M. Perreault, Qingcong Lin, R. Gimeno   +12 more
semanticscholar   +1 more source

Polymorphisms in CLOCK and ARNTL/BMAL-1 genes in multiple sclerosis: a systematic review and meta-analysis. [PDF]

Eur J Med Res
Oladghaffari M, Bandehagh H, Malekinejad F, Fakhkhari S, Koohi N, Moghaddamziabari S, Hamzehzadeh S, Mohammadian E, Talebi M, Salehi-Pourmehr H, Naseri A.   +10 more
europepmc   +1 more source

Loss of Schwann cell's normal rhythmic core clock gene expression and gain of rhythmic expression of oncogenic driver genes in malignant NF1-associated peripheral nerve sheath tumor. [PDF]

Mol Cell Oncol
Leisz S, Pelligrino A, Fritzsche S, Wiegers M, Wösle M, Linke C, Lohse S, Tippner D, Scheller C, Strauss C, Ehrentreich-Förster E, Dehghani F, Sys S, Maronde E, Harder A.   +14 more
europepmc   +1 more source