Results 61 to 70 of about 563,634 (267)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Dynamic Risk Trajectories for Sudden Cardiac Arrest: The Role of Recurrent Cardiovascular Events

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Although cardiovascular events increase sudden cardiac arrest (SCA) risk, the impact of recurrent events on subsequent SCA risk in a contemporary population is unknown.
Marita Knudsen Pope, Harpriya Chugh, Thien Tan Tri Tai Truyen, Marco Mathias, Audrey Uy‐Evanado, Honghuang Lin, Dan Atar, Nichole Bosson, Kyndaron Reinier, Emelia J. Benjamin, Sumeet S. Chugh   +10 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

GUARANTEES OF THE LEGALITY AND VALIDITY OF THE LIMITATION OF PERSONAL IMMUNITY

Хабаршы. Заң сериясы, 2018
The article gives a theoretical analysis of measures of state coercion, observance of the principle of inviolability of the person when applying measures of criminal procedural coercion.
Mukhamadiyeva G.N., Kasymbek A.O.
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hapšenje Milivoja Trbića u januaru 1947. [PDF]

Istorija 20. Veka, 2014
This article has an aim to make a reconstruction of the arrest of Milivoj Trbić. He was arrested by the Administration of State Security on January 16, 1947 in the Prilep village Zrze.
Aleksandar Simonovski
doaj  

Emergency clamshell thoracotomy in blunt trauma resuscitation: Shelling the paradigm‐2 cases and review of the literature

Clinical Case Reports, 2018
Key Clinical Message Clamshell thoracotomy (CST) may be indicated and life‐saving in carefully selected cases of blunt trauma. As such, the current clinical stance of general contraindication of CST in blunt trauma should be reviewed and criteria ...
Patrick Schober, Marcel A. de Leeuw, Maartje Terra, Stephan A. Loer, Lothar A. Schwarte   +4 more
doaj   +1 more source

Citations and Convictions: One Community’s Coordinated Response to Intimate Partner Violence & Efforts toward Offender Accountability

Social Sciences, 2015
In 1996, a coordinated community response (CCR) was formally established in a mid-sized Midwestern city to improve the criminal justice response to intimate partner violence (IPV). Data for this study included all IPV-related incidents to which the local
Kerry Beldin, Allison Lauritsen, Henry D'Souza, Bob Moyer   +3 more
doaj   +1 more source