DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis
Advanced Science, EarlyView.This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li +25 more
wiley +1 more source
Improved active current limiting control for flexible DC power grid to consider the effects of selective and higher fault resistance. [PDF]
Sci RepQin X, Hou J, Fan Y, Song G, Wu X.
europepmc +1 more source
Advanced Science, EarlyView.This review provides a comprehensive exploration of microstructure regulation strategies for multi‐principal element alloy‐based films and coatings, with a focus on the interplay between elemental composition, nanoscale architecture, heterostructures and interfacial engineering in tailoring their properties and functions. A systematic analysis of their
Jiaming Cao +4 more
wiley +1 more source
Optimal application research of superconducting fault current limiters on medium voltage direct current shipboard power system. [PDF]
Sci RepZhou Y, Ren L, Xu Y, Shi J.
europepmc +1 more source
KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation
Advanced Science, EarlyView.This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho +6 more
wiley +1 more source
High-Precision Tunneling Magnetoresistance (TMR) Current Sensor for Weak Current Measurement in Smart Grid Applications. [PDF]
Micromachines (Basel)Xu Y, Jin Z, Chen J.
europepmc +1 more source
A narrative review of hydrogen-oxygen mixture for medical purpose and the inhaler thereof. [PDF]
Med Gas Res, 2020 Lin HY, Lai PC, Chen WL.
europepmc +1 more source
Reduction of the visual impact of overhead transmission line systems through utilisation of line surge arresters as lightning protection [PDF]
, 2008 Holbøll, Joachim +1 more
core
Advanced Science, EarlyView.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source