Results 81 to 90 of about 2,843 (250)

FUZZY MODELING OF FAILURE PROBABILITY OF APARATES FOR PROTECTION FROM OVERVOLTAGE

Elektrotehnìka ta Elektroenergetika, 2018
Purpose. The aim of the article is to develop a mathematical model for a comprehensive assessment of the probability of failure of an overvoltage protection device using a fuzzy set device, which is based on expert knowledge and diagnostic data obtained ...
S.V. Domoroshchyn, O.A. Sakhno
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Spark Arrester

, 1909
Patent for spark arrester. This invention is adapted for use with locomotives.
Ridgway, Elzie L.
core  

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Spark-Arrester

, 1910
Patent for a spark arrester designed to extinguish the glowing cinders of smoke stacks.
Goodrich, Luman L., Jr.
core  

Statistical approach for insulation coordination of high voltage substation exposed to lightning strikes

Electrical engineering & Electromechanics
Introduction. Insulation coordination requires accurate prediction of overvoltages at various points within a substation. Computer simulations of electromagnetic transients in real structures of substations become more precise due to the improvements of ...
S. Bedoui, A. Bayadi
doaj   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Study on the Failure Causes and Improvement Measures of Arresters in 10 kV Distribution Transformer Areas

Energies
In recent years, arresters in 10 kV distribution transformer areas of the Guangdong power grid have exhibited a rising trend of premature failures, posing a serious threat to distribution network reliability.
Taishan Hu, Yuanzhi Wu, Zhiming Liao, Gang Liu, Shangmao Hu, Yongxia Han, Lu Qu, Licheng Li   +7 more
doaj   +1 more source