QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study
Advanced Science, EarlyView.The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda +8 more
wiley +1 more source
Development and practical application of condition monitoring system for ultra-high voltage electrical equipment. [PDF]
Sci RepHu S, Meng M.
europepmc +1 more source
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
Research on the Resistance and Flame Retardant Performance of Flame Arresters in Low-Concentration Coalbed Methane Pipelines. [PDF]
ACS OmegaXiao L +6 more
europepmc +1 more source
Configuring the metal-oxide surge arresters
, 2019 U ovom završnom radu pod naslovom Izbor metal oksidnih odvodnika prenapona, detaljno je opisana opasnost koja nastaje pojavom prenapona i važnost zaštite elektroenergetskog sustava s odvodnicima prenapona.
Stjepanović, Dean
core
Advanced Science, EarlyView.TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang +12 more
wiley +1 more source
Shielding failure analysis of extra high voltage unconventional transmission lines with increased power delivery capability. [PDF]
Sci RepArafat E, Ghassemi M.
europepmc +1 more source
Structure of Surge Arresters and Their Application in Power System
, 2010 This work deals with internal and external protection against surge phenomena occurring in the power system. Describes the atmospheric and the operating overvoltage.
Strapko, Miroslav
core
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
A Degradation Warning Method for Ultra-High Voltage Energy Devices Based on Time-Frequency Feature Prediction. [PDF]
Sensors (Basel)Zhao P, Wang L, Wei J, Wang Y, Wu H.
europepmc +1 more source